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6 articles for “LC-MS/MS analysis”
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Quantification of Chemical Components and Phytochemical Screening of GaliumVerum by HPLC and LC-MS Analysis
Abstract: Galium verum L. – yellow "Lady's bedstraw" – contains polyphenols, flavonoids, phenyl- propanoids compounds, and iridoids in its golden yellow blossoms. The chemical makeup of the volatile fraction of Galiumverum L. was analysed.This plant is from the natural flora of Moldova (RediuIasi region, Romania) as a source of polyphenols and flavonoids.The purpose of this investigation is to investigate the composition of the herb methanol extract of Lady's bedstraw (Galium verum …
Published in International Journal of Agrochemistry · Vol. 9, Issue 1, 2023 · pp. 1–7 Read article
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Quantification of Morphine, Codeine, and Dihydrocodeine in Carissa carandas Leaves and Fruit Using LC-MS/MS: The Impact of Drying on Alkaloid Concentration
Abstract: This study presents a method for quantifying morphine, codeine, and dihydrocodeine in Carissa carandas (Karonda) leaves and fruit, employing morphine-D3 as an internal standard (1 µg/mL) to ensure accuracy. Samples are prepared at 25 ng/mL and extracted using solvent techniques, with an optional solid-phase extraction step to mitigate matrix effects. Quantification is conducted via LC-MS/MS, providing robust sensitivity. Results show that drying concentrates these alkaloids, particularly morphine in fruit, due …
Published in International Journal of Environmental Chemistry · Vol. 11, Issue 1, 2025 · pp. 49–61 Read article
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High-Performance Thin-Layer Chirography Detection of Ethambutol
Abstract: Ethambutol belongs to the class of organic compounds known as 1, 2 amino alcohols. Being a medication, it is primarily used to treat tuberculosis. Its route of administration is oral. It is readily absorbed by gastrointestinal tract and 50% excreted unchanged by urine. Capacity of protein binding is 20–30%. It is antitubercular agent i.e. inhibiting the synthesis of spermidine in myobacteria also inhibits the transfer of mycolic acids into cell …
Published in International Journal of Industrial Biotechnology and Biomaterials · Vol. 4, Issue 1, 2018 · pp. 31–33 Read article
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Establishment of a Sensitive LC-MS Method for Pharmacokinetic Evaluation of Decitabine and Cedazuridie in Rat Plasma
Abstract: A simple, rapid, and highly sensitive liquid chromatography–mass spectrometry (LC–MS) method was successfully developed and validated for the simultaneous determination of Decitabine and Cedazuridine in plasma matrices. The method demonstrated excellent linearity across the selected calibration range, with correlation coefficients (R²) consistently exceeding 0.999 for both analytes, indicating strong analytical performance. Method validation was carried out in accordance with ICH Q2(R2) and US FDA bioanalytical method validation guidelines, ensuring compliance …
Published in International Journal of Green Chemistry · Vol. 12, Issue 1, 2026 · pp. 34–42 Read article
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Establishment of a Sensitive LC-MS Method for Pharmacokinetic Evaluation of Decitabine and Cedazuridie in Rat Plasma
Abstract: Abstract A simple, rapid, and highly sensitive liquid chromatography–mass spectrometry (LC–MS) method was successfully developed and validated for the simultaneous determination of Decitabine and Cedazuridine in plasma matrices. The method demonstrated excellent linearity across the selected calibration range, with correlation coefficients (R²) consistently exceeding 0.999 for both analytes, indicating strong analytical performance. Method validation was carried out in accordance with ICH Q2(R2) and US FDA bioanalytical method validation guidelines, ensuring …
Published in International Journal of Green Chemistry · Vol. 12, Issue 1, 2026 · pp. 34–42 Read article
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Larvicidal Activities of Biosynthesized Zinc and Nickel Nanoparticles using Allium sativum (Garlic) oil on Anopheles spp Larvae Yobe State, Nigeria
Abstract: Emergence of insecticide resistance and their harmful effects on non-target organisms and environment has necessitated an urgent search for development of new and improved mosquito control methods that are effective and safe for non-target organisms and the environment. The present study aims to assess the larvicidal activities of biosynthesized zinc and Nickel Nanoparticles using Allium sativum (garlic) oil against the larvae of malaria Anopheles spp. The garlic oil extracted was …
Published in International journal of Nanobiotechnology · Vol. 7, Issue 2, 2021 · pp. 1–9 Read article