All articles
127 articles
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Cryogenic Electron Microscopy Reveals Conformational Dynamics and Catalytic Mechanisms of Human Fatty Acid Synthase in De Novo Lipid Biosynthesis
Abstract: Fatty acid synthase (FASN) is a multifunctional homodimeric enzyme central to de novo fatty acid synthesis in mammals. Recent cryogenic electron microscopy (cryo-EM) studies have illuminated the structural basis of FASN catalysis, revealing multiple conformational states throughout the synthesis cycle. These findings show that the acyl carrier protein (ACP) domain dynamically shuttles substrates between spatially separated active sites, while the condensing and modifying regions remain structurally stable. In contrast to …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 2, 2026 · pp. 8–25 Read article
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General and Organic Chemistry Laboratory Experiments for Science, Pre-medical, and Pharmacy Students – Chapter V: Organic Synthesis
Abstract: Organic synthesis can be classified into many types, including simple one-step synthesis, multi-step, one-pot, microwave, or green synthesis. Each type of synthesis takes place through a specific pathway depending on reactants involved, the reaction conditions, the catalyst, the protection group, and the duration of the reaction. In some cases, the required compound can be prepared by more than one procedure, and an expert chemist prefers the procedure by which the …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 2, 2026 · pp. 8–16 Read article
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Photo-Catalytic Degradation of Dyes Using Graphene Oxide–Dithizone Composite
Abstract: Graphene oxide–dithizone (GO–DTZ) composite was successfully synthesized through the copolymerization of graphene oxide and dithizone to develop an efficient photocatalytic material for wastewater treatment. The dithizone polymer was prepared using a 1:2 molar ratio, while graphene oxide was synthesized via the modified Hummers’ method to obtain highly oxidized graphene sheets with abundant oxygen-containing functional groups. The GO–DTZ nanocomposite was fabricated by ultrasonically dispersing graphene oxide with the synthesized dithizone polymer …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 2, 2026 · pp. 46–53 Read article
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Spatial Variation and Pollution Assessment of Selected Water Quality Variables in the Luubara Creek, Niger Delta, Nigeria
Abstract: The spatial variation and pollution status of selected water quality variables in Luubara Creek, Niger Delta, Nigeria, were assessed between June and August 2024. Water samples were collected from four sampling stations, with Stations 1 and 2 representing areas of relatively low anthropogenic influence and Stations 3 and 4 representing areas with greater human activities. Physicochemical parameters and heavy metals were analyzed following the standard methods of the American Public …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 2, 2026 Read article
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Chemistry of Mehandi (Henna): Natural Dyeing Mechanism, Composition, and Applications
Abstract: Mehandi (Henna), derived from the plant Lawsonia inermis, is one of the oldest natural dyes used for body art, hair coloring, and traditional medicinal applications. Beyond its cultural significance, henna represents an interesting example of applied organic chemistry, where naturally occurring molecules interact with biological tissues to produce long-lasting coloration. The primary coloring constituent of henna is Lawsone (2-hydroxy-1,4-naphthoquinone), a naphthoquinone compound responsible for the characteristic reddish-brown stain. When henna …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 2, 2026 · pp. 39–45 Read article
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Agro Seed Oil Production through Mechanothermal Extraction: Exploring its Potential for Chemical, Pharmaceutical, and Food Industries
Abstract: The increasing demand for sustainable and environmentally friendly industrial raw materials has intensified research into the production of oils from agro seeds using efficient extraction technologies. This study reviews the mechanothermal extraction of agro-seed oils with emphasis on their potential applications in chemical, pharmaceutical, and food industries. Mango (Mangifera indica) seeds, which are commonly discarded as agricultural waste during fruit processing, contain significant quantities of lipids, proteins, carbohydrates, antioxidants, and …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 2, 2026 Read article
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Synthesis, Structural Elucidation, and Antimicrobial Screening of a Cobalt (II) Coordination Compound Derived from a Thiophene-Containing Schiff Base
Abstract: Abstract An N, O-chelating azomethine Schiff base ligand (HL), chemically identified as 2-{[(thiophen-2-yl) methylidene] amino} benzoic acid, was synthesized by an equimolar condensation reaction between thiophene-2-carbaldehyde and anthranilic acid in absolute ethanol in the presence of a catalytic amount of acetic acid. The corresponding cobalt (II) complex, formulated as [Co(L)₂] · 2H₂O, was prepared by refluxing two equivalents of the ligand with one equivalent of cobalt (II) acetate tetrahydrate in …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 2, 2026 · pp. 1–7 Read article
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General and Organic Chemistry Laboratory Experiments for Science , Pre-medical, and Pharmacy studentsChapter IV: Identification and Purification of Organic Compounds
Abstract: In order to identify an organic compound, a chemist needs to apply the suitable technique, depending on the compound state. Accordingly, melting point identification is applied for solids, boiling point for liquids, and sublimation for some compounds which have the tendency to sublime. On the other hand, When an organic compound is isolated from its natural source such as plants, it can be contaminated with some other undesirable compounds, called …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 1, 2026 · pp. 43–59 Read article
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Advances in Applied Chemistry: From Electrochemical Biosensors and Gas Sensing to Sustainable Remediation and Nanofluid Engineering
Abstract: Applied chemistry acts as a crucial link between fundamental molecular science and practical technological innovation. It transforms theoretical knowledge into real-world applications that address challenges in healthcare, environment, and industry. This review highlights recent advancements in electrochemical biosensors, which offer rapid and sensitive diagnostic capabilities, along with modern gas detection technologies designed for improved safety and environmental monitoring. Significant attention is given to environmental remediation, particularly the use of activated …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 1, 2026 · pp. 20–25 Read article
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Green and Nanotechnology Approaches for the Determination of Tungsten (VI): A Modern Analytical Perspective
Abstract: The determination of tungsten (VI) has gained increasing importance due to its extensive industrial applications and growing environmental relevance. Tungsten is widely used in alloys, catalysts, electronics, and energy systems, leading to its release into environmental matrices such as water, soil, and biological systems. Accurate monitoring of tungsten at trace and ultra-trace levels is therefore essential for environmental assessment and industrial quality control. Conventional analytical techniques, including inductively coupled plasma …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 1, 2026 · pp. 26–35 Read article
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Recent Advances in Analytical and Applied Chemistry: A Comprehensive Review
Abstract: Analytical and Applied Chemistry form the backbone of modern scientific progress, connecting fundamental molecular insights with real-world industrial and societal applications. Over the past decade, these fields have undergone significant transformation, driven by the need for sustainability, precision, and efficiency. This review highlights key advancements in green analytical chemistry (GAC), high-resolution mass spectrometry (HRMS), and the incorporation of nanotechnology into chemical sensing, while also examining their broader implications in applied …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 1, 2026 · pp. 36–41 Read article
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Synthesis, Characterization, Chromatographic and Antifungal Evaluation of New Chalcone-Azo Ligand and Complexes
Abstract: Ligand chemistry is fundamental to coordination chemistry, complex chemistry, analytical reagents, andthe treatment of heavy ion pollutants. Recently, ligand complexes have been used in biologicalapplications such as radiation and the treatment of certain types of tumors. Researchers have expandedtheir studies to include complexes such as nanomaterials and drug carriers, demonstrating theireffectiveness through their nanoscale properties. It is worth noting that we chose indole and linked it to achalcone group to …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 1, 2026 · pp. 10–19 Read article
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Analytical Evaluation of heavy metals in eyeshadows: A Risk assessment and Implications for Public Health Regulatory Reforms in Nigeria
Abstract: This study employs advanced analytical techniques to assess heavy metal contamination (Pb, Cd, Cr, Ni, Zn) in 18 commercially available eyeshadow products (local and imported) from Owerri Metropolis, Nigeria. Quantification was conducted using atomic absorption spectroscopy (AAS), while risk evaluations incorporated chemometric modeling approaches. Results revealed significant contamination in locally manufactured brands, particularly those containing calabash chalk (Nzu) as a base ingredient. Lead and nickel concentrations reached 166.58 ± 6.5 …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 1, 2026 Read article
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Uses of Natural Fibres in Polymer Composites
Abstract: The increasing demand for sustainable and eco-friendly materials has led to growing interest in utilizing natural fibers as reinforcements in polymer composites. Natural fibers such as jute, flax, hemp, sisal, and coir have gained notable attention due to their renewable origin, biodegradability, low density, and cost-effectiveness when compared with conventional synthetic fibers like glass or carbon. When combined with suitable polymer matrices, these fibers form natural fiber-reinforced polymer composites (NFRPCs), …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 1, 2026 · pp. 1–9 Read article
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Use of Titanium as filter on chimney
Abstract: Industrial chimneys are one of the largest contributors to air pollution, releasing a wide range of harmful gases and fine particulate matter into the atmosphere. These emissions significantly degrade environmental quality and contribute to long-term public health risks such as respiratory diseases and cardiovascular complications. Traditional air pollution control devices used in industrial exhaust systems, including electrostatic precipitators and bag filters, often struggle with high operational costs, frequent maintenance, and …
Published in International Journal of Analytical and Applied Chemistry · Vol. 11, Issue 2, 2025 · pp. 120–126 Read article
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Statistical Modeling of Diffusion of Heavy Metals from Waste Oil in Soil Environment Using Regression Analysis
Abstract: Regression analysis is a statistical tool or method used to estimate the relationship between dependent variable and one or more independent variables. The diffusion and statistical model of heavy metals in soil are critical factors influencing pollutant migration and environmental remediation strategies. Understanding the diffusion and statistical method of analyzing the adsorption of heavy metals in soils is crucial for assessing environmental contamination and designing effective remediation strategies. This study …
Published in International Journal of Analytical and Applied Chemistry · Vol. 11, Issue 2, 2025 · pp. 1–15 Read article
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Mathematical Modeling of Mass Transfer of Heavy Metals from the Diffusion of Condemned Oil in Soil Environment
Abstract: The diffusion and reaction kinetics of heavy metals in soil are critical factors influencing pollutant migration and environmental remediation strategies. Understanding the diffusion and reaction kinetics of heavy metals in soils is crucial for assessing environmental contamination and designing effective remediation strategies. This study investigated the diffusion behavior of heavy metals in soil media under varying thermal and physical conditions, employing a first- order reaction model based on Fick’s second …
Published in International Journal of Analytical and Applied Chemistry · Vol. 11, Issue 2, 2025 Read article
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Synthesis, computational analysis and biological evaluation of novel thiazolidinone derivatives
Abstract: Through multicomponent methods including 2-chloroquinoline-3-carbaldehyde,(1- methylpiperidin-4-yl) methanamine and thioglycolic acid, the work focuses on creating and assessing the antibacterial characteristics of a new 4-thiazolidinone heterocyclic. Spectral testing was used to validate the molecules' structures. All the compounds were screened for their antibacterial and antifungal activity using Agar-well diffusion; compared to the reference drugs such as Ampicillin, Ciprofloxacin, and Griseofulvin, the examined compounds demonstrated moderate to good efficacy, with inhibition zone …
Published in International Journal of Analytical and Applied Chemistry · Vol. 11, Issue 2, 2025 · pp. 30–40 Read article
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Technical Insights into the Industrial Synthesis and Production of Ten Prominent Plant Growth Regulator Molecules: Process Flow and Mass Balance Determination
Abstract: Plant Growth Regulators (PGPRs) are indispensable tools in modern agriculture, offering precise control over various aspects of plant development and enhancing crop productivity. While their diverse applications are widely recognized, detailed technical insights into their industrial manufacturing processes, including synthesis routes, process flow, and mass balance, are often limited. This manuscript addresses this gap by presenting a comprehensive technical analysis of the industrial synthesis and production of ten prominent PGPR …
Published in International Journal of Analytical and Applied Chemistry · Vol. 11, Issue 2, 2025 Read article
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Topical Application of Grape Seed Oil and Linalool, and Treating the Mulberry Leaves with Aqueous Solution of Drakshsava Before Feeding the Fifth Instars of Silkworm, Bombyx mori (L), for Qualitative Silk Cocoons.
Abstract: Nutrition quality and health of larval-instars exert influence on silk-yield-quality. Ten microliters of Acetone- solutions of Grape-Seed-Oil (10 ml Grape-Seed-Oil dissolved in 90 ml acetone) and acetone solutions of Linalool (100 ppm) were used separately in present attempt for the topical application to the fifth instar larval stages of silkworm, Bombyx mori (L). Group of larvae fed Mulberry-leaves treated with aqueous solution Drakshasav; group of larvae topically applied with acetone …
Published in International Journal of Analytical and Applied Chemistry · Vol. 11, Issue 2, 2025 · pp. 30–40 Read article