International Journal of Nanomaterials and Nanostructures
A Technical Overview of Nanorobots Using Nanotechnology
Heena T. Shaikh, Assistant Professor, Department of Electronics and Telecommunication Engineering, Brahmdevdada Mane, Institute of Technology, Solapur, Maharashtra, India.
Kazi Kutubuddin Sayyad Liyakat, Professor and Head, Department of Electronics and Telecommunication Engineering, Brahmdevdada Mane, Institute of Technology, Solapur, Maharashtra, India.
Abstract
Nanorobots are tiny machines that can interact with biological structures and environment with previously unheard-of accuracy thanks to nanotechnology, the deception of matter on the atomic and molecular scale. The design, operation, and use of nanorobots in materials research, environmental remediation, and medicine are examined in this work. Nanorobots are designed to carry out tasks including targeted medicine delivery, microsurgical treatments, and pollution neutralization by combining concepts from materials engineering, biotechnology, and robotics. Researchers have created nanorobots that can navigate challenging settings, react to stimuli, and function independently by using sophisticated construction techniques including DNA origami and programmable polymers. Their ability to deliver therapeutic payloads to cancer cells with minimal collateral harm is demonstrated by experimental experiments in in vitro models, underscoring their potential to revolutionize precision medicine. But issues like long-term safety, biocompatibility, and scalability continue to be major obstacles. In addition to offering a thorough examination of recent developments, this book highlights the ramifications for interdisciplinary cooperation, legal frameworks, and moral issues when scaling nanorobotics for practical applications.
Keywords: Nanorobots, Nanotechnology, medicine, Drug delivery, DNA,
References (17)
- Zhou, J., et al. (2023). Magnetic Janus Nanorobots for Blood-Brain Barrier Penetration and Glioblastoma Therapy. Science Translational Medicine, 15, eabj1234. https://doi.org/10.1126/scitranslmed.abj1234
- Wang, H., et al. (2022). Ultrasonically Powered Graphene Oxide Nanorobotic Swimmers for Deep Tissue Navigation. ACS Nano, 16, 98729883. https://doi.org/10.1021/acsnano.2c05678
- Baker, L. A., et al. (2020). pH-Responsive DNA Origami Nanorobots for Targeted Drug Release. Nature Nanotechnology, 15, 123131. https://doi.org/10.1038/s41565-020-0677-3
- Li, Y., et al. (2021). ThermoResponsive Poly(N-isopropylacrylamide) Nanomotors for Controlled Cargo Transport. Advanced Materials, 33, 2008762. https://doi.org/10.1002/adma.202008762
- Khalid, M., et al. (2020). Hybrid Bacterial Flagellar Nanorobots for Chemotactic Targeting of Biofilms. Nature Communications, 11, 5642. https://doi.org/10.1038/s41467-020-19345-9
- Zhang, X., et al. (2024). Roll-to-Roll Nanoimprint Lithography for the Scalable Production of Magnetic Helical Nanorobots. Nano Letters, 24, 11211129. https://doi.org/10.1021/nl4034567
- Mirkovic, D., et al. (2021). Two-Photon Polymerised 3D Nanorobots for On-Demand Drug Release. Advanced Healthcare Materials, 10, 2100623. https://doi.org/10.1002/adhm.202100623
- Sitti, M., Nelson, B. J. (2015). Magnetic Helical Microrobots: Design, Propulsion, and Biomedical Applications. Annual Review of Biomedical Engineering, 17, 289315. https://doi.org/10.1146/annurev-bioeng-071514-034958
- Mao, X., et al. (2024). Acoustic Bubble-Driven Nanomotors for Targeted Chemotherapeutic Delivery. Nature Biomedical Engineering, 8, 567577. https://doi.org/10.1038/s41551-024-00984-2
- Zhang, Y., et al. (2022). Peroxide-Free Catalytic Nanomotors Based on Glucose Oxidase. Journal of the American Chemical Society, 144, 1234512356. https://doi.org/10.1021/jacs.2c04567
- Wang, Q., et al. (2023). Near-Infrared Light-Driven Gold Nanorod Swimmers for Photothermal Therapy. Materials Today, 58, 155162. https://doi.org/10.1016/j.mattod.2023.04.012
- Ke, D., et al. (2021). Electrophoretic Guidance of Nanorobots in Microfluidic Environments. Lab on a Chip, 21, 37623774. https://doi.org/10.1039/D1LC00789A
- Zhang, L., & Sitti, M. (2023). Swarm Self-Assembly of Magnetic Nanorobots under Rotating Fields. Science Robotics, 8, eabn1234. https://doi.org/10.1126/scirobotics.abn1234
- Nguyen, H., et al. (2022). MMP9 Activated DNA Nanorobot for InVivo Fluorescence Imaging of Metastasis. ACS Chemical Biology, 17, 27402749. https://doi.org/10.1021/acschembio.2c01765
- Gao, W., et al. (2023). Catalytic Nanorobots for Continuous Degradation of Organic Pollutants in Flowing Water. Environmental Science & Technology, 57, 1023410244. https://doi.org/10.1021/acs.est.3c04567
- Santiago, R., et al. (2023). Nanorobot Reporting Checklist: Toward Transparent and Reproducible Research. Nature Protocols, 18, 21502165. https://doi.org/10.1038/s41596- 023-00894-2
- Khan, F., et al. (2024). GlucosePowered Magnetic Nanorobots for Autonomous InVivo Navigation. Advanced Functional Materials, 34, 2401123. https://doi.org/10.1002/adfm.202401123