Use of PARP Inhibitor in Cancer Cell Progression

Jyoti Gupta

International Journal of Animal Biotechnology and Applications

Use of PARP Inhibitor in Cancer Cell Progression

Jyoti Gupta

Abstract

DNA damage response (DDR) is the cellular mechanism plays specific role of repairing during genotoxic injuries through specific mechanism of action. The DDR defects involve genomic instability and enhance tumor progression but when molecular alterations occurs in the cells become more susceptible to the pharmacological inhibition of the DNA repairing enzymes.Targeting cellular proteins like poly-ADP-ribose polymerase (PARPs) alters protein structure and function and favors molecular defects of the DDR process by bringing a specific lethality in DDR defective cancer cells and represents an anti-cancer strategy.Normal cells can bear the DNA damage produced by PARP inhibition due to an effective homologous recombination mechanism (HR); similarly, cancer cells with lacking HR become sensitive to the PARP inhibitors (PARPi) effects as they also lack the repairing mechanism of DSBs. Keywords: DNA damage response, genotoxic, PARP, homologous recombination

Full text

The full text of this article is available to subscribers.

On a subscribing campus you are let in by network address, with no login at all.

One-off purchase. Permanent access to this article, no account needed.

A year of online access to every article in International Journal of Animal Biotechnology and Applications. Or choose several journals →

Article details

Use of PARP Inhibitor in Cancer Cell Progression

Abstract

Read more of it

Publish your article

Abstract

Related articles

Animal Biotechnology: Finding a Balance Between New Ideas and Morality

Spermmediated gene transfer revisited: optimizing delivery, integration, and germline transmissionin large animal models

Stem Cell and Cloning Technologies in Livestock Improvement: Advances, Applications, and Future Prospects for Sustainable Animal Production and Genetic Improvement

Barriers to Advanced Reproductive Technologies in the Subsistence Dairy Farming Systems: Key Constraints andthe Way Forward

Barriers to Advanced Reproductive Technologies in the Subsistence Dairy Farming Systems: Key Constraints and the Way Forward

Read more of it

Publish your article