2 publications

• Published Subscription 29 Mar 2019

  Use of PARP Inhibitor in Cancer Cell Progression

  By Jyoti Gupta

  Abstract: DNA damage response (DDR) is the cellular mechanism plays specific role of repairing during genotoxic injuries through specific mechanism of action. The DDR defects involve genomic instability and enhance tumor progression but when molecular alterations occurs in the cells become more susceptible to the pharmacological inhibition of the DNA repairing enzymes.Targeting cellular proteins like poly-ADP-ribose polymerase (PARPs) alters protein structure and function and favors molecular defects of the DDR process …

  Published in International Journal of Animal Biotechnology and Applications · Vol. 4, Issue 2, 2018 · pp. 24–35 Read article →

• Published Subscription 19 Nov 2018

  In Vitro Evaluation of Bioremediation Capacity of a Commercial Probiotic, Bacillus clausii, for Chromium (VI) and Lead (II) Toxicity

  By Jyoti Gupta, Seema Dwivedi

  Abstract: Heavy metals cause disastrous effects on any living organisms. Probiotics have the ability to reduce metal toxicity. Commercial probiotics having bioremediation capacity can use these bacteria as an alternative to conventional remediation methods. The bioaccumulation of heavy metals including chromium (VI) (Cr [VI]) and lead (II) (Pb [II]) causes fatal toxicity in humans. Some naturally occurring bacterial species, such as Bacillus and Pseudomonas, contribute their role in bioremediation of these …

  Published in International Journal of Industrial Biotechnology and Biomaterials · Vol. 4, Issue 2, 2018 · pp. 1–16 Read article →