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Autoimmune Polyglandular Syndrome Type 1 (APS-1): A Rare Yet Crucial Condition to Recognize
Abstract: Autoimmune Polyglandular Syndrome Type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED), is a rare autosomal recessive disorder caused by mutations in the AIRE (Autoimmune Regulator) gene. This syndrome is characterized by a triad of chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenal insufficiency, although it can affect multiple other organ systems. APS-1 arises from a failure of central immune tolerance, resulting in autoimmunity against various endocrine and non-endocrine tissues. The …
Published in International Journal of Immunological Nursing · Vol. 11, Issue 1, 2025 Read article