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Xerostomia and Salivary Gland Hypofunction: From Pathophysiology to Nanotechnology‑Enabled Regenerative Therapies
Abstract: Xerostomia, the subjective sensation of oral dryness, is a common yet frequently underrecognized condition with multifactorial etiology and substantial consequences for oral and systemic health. Salivary gland hypofunction underlies many, but not all, cases and may result from medication use, head and neck radiotherapy, autoimmune disease, systemic illnesses, or age-related and hormonal changes. Persistent xerostomia impairs mastication, swallowing, speech, taste, and sleep, and predisposes to dental caries, periodontal disease, oral …
Published in International journal of Nanobiotechnology · Vol. 12, Issue 1, 2026 · pp. 1–27 Read article