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57 articles for “solubility”
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Solubility Enhancement of Theophylline Drug Using Mixed Solvency Approach
Abstract: “Solubility enhancement” is one of the difficult tasks that have become a great challenge in formulation development of orally administered drugs having poor aqueous solubility. Poor aqueous solubility of drugs creates significant problems in producing formulations of sufficiently high bioavailability, thereby preventing the effective usage of these drugs. With the introduction of the concept of “mixed-solvency,” it is feasible to increase the solubility of poorly water-soluble drugs in aqueous solutions …
Published in International Journal of Chemical Separation Technology · Vol. 1, Issue 2, 2015 · pp. 1–4 Read article
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Nanosuspension-novel Technique for Solubility Enhancement
Abstract: In the treatment of many diseases, getting medicinal compounds to the desired location is a serious issue. Poor biodistribution, limited effectiveness, unfavorable side effects, and a lack of selectivity define traditional medication use. Different types of nanostructures are produced using various size reduction processes and technologies, each with its own set of physicochemical and biological features. These technologies make nanostructures a good material for biomedical applications, and they've gained a …
Published in International Journal of Nanomaterials and Nanostructures · Vol. 7, Issue 2, 2021 · pp. 18–24 Read article
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Turn-On” Fluorescence Sensing of Bilirubin Using Water-Soluble Conjugated Polymer
Abstract: Early detection of bilirubin is important to detect jaundice and hepatitis disease at the early stage. Currently, there is no fast method available to detect bilirubin level directly in the presence of crucial interference. This report presents a novel water-soluble poly(fluorenes-alt-benzothiadiazole) for turnon sensing of bilirubin in water and human blood serum. The probe is the water-soluble conjugated polymer poly(fluorenes-alt-benzothiadiazole) functionalized with a D-glucuronic acid named PF-BTGlcA. D-glucuronic acid acts …
Published in International Journal of Analytical and Applied Chemistry · Vol. 7, Issue 2, 2021 · pp. 13–20 Read article
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Synthesis of White Light Emitting Water-soluble CdZnS Quantum Dots at Room Temperature
Abstract: Water-soluble alloyed CdZnS quantum dots (QDs) have been successfully prepared at room temperatures by reacting a mixture of Cd(CH3COO)2 and Zn(CH3COO)2 with Na2S using thiolactic acid (TLA) as a surface capping agent. The photoluminescence (PL) spectra of the alloyed QDs are determined on the basis of the Cd2+/Zn2+ molar ratio, reaction pH, intrinsic Cd2+and Zn2+reactivities toward Na2S and the concentration of capping agent. A systematic blue shift in emission wavelength …
Published in International Journal of Energetic Materials · Vol. 7, Issue 1, 2021 · pp. 32–39 Read article
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Protein Determination and Soluble Amino Acids Prediction in Various Solvents Extracted Solutions of Indigenous Red Lentil and Moong Pulse through Direct UV- Visible Spectrophotometer Technique: A Comparative Study
Abstract: In this comparative study, direct protein determination have been done for indigenous Red lentil (Lens culinaris) and Moong pulse (Vigna radiata) (obtained from Muzaffarpur, Bihar) by UV-Visible spectroscopy in three different solvents viz. double distilled water (ddH2O), ethyl alcohol (C2H5OH), and methyl alcohol (CH3OH). A few amino acids in solutions have also been predicted (not characterized) based on their peaks observed in UV-region by comparing them with reported range of …
Published in International Journal of Plant Biotechnology · Vol. 9, Issue 2, 2023 · pp. 42–48 Read article
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A Review Paper on Novel Lipid Nanoparticles for Enhanced Bioavailability of Bioactive Compounds in Breast Cancer Cell Lines
Abstract: Most bioactive compounds from natural products are heavily relied on drug development due to their biological, chemical and pharmacological properties. Some compounds exhibiting anticancer properties have also been reported. However, they present a challenge in achieving the effective absorption and delivery in the body. This is due to minimal bioavailability, fluctuation of plasma drug concentration, low tolerance, first-pass effect which leads to less desired efficacy. Therefore, this calls for an …
Published in International Journal of Composite and Constituent Materials · Vol. 10, Issue 1, 2024 · pp. 1–9 Read article
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Investigation of Thermo-Acoustic Properties of Ethanol-Cyclohexane Binary Mixture
Abstract: The density, viscosity, and speed of sound for ethanol-cyclohexane binary mixtures were determined across mole fractions ranging from 0.1 to 0.9 using an Anton Paar DSA 5000 M within the temperature span of 288.15–318.15 K. From these experimental measurements, several thermodynamic and acoustic properties, such as isentropic compressibility, relative association, free volume, relaxation time, Gibbs free energy of activation, internal pressure, and solubility parameter, were derived. These parameters serve as …
Published in International journal of Thermodynamics and Chemical Kinetics · Vol. 11, Issue 2, 2025 · pp. 1–14 Read article
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Investigation of the Compatibility of Binary and Ternary Polymer Systems
Abstract: We have obtained mechanical strength of materials as a result not by synthesizing new polymers, but by using industrial polymers. We have developed a technology for obtaining new composite materials based on industrial multi-tonnage polymers of high-strength polyethylene (HSPE), polyvinyl chloride (PVC), polyurethane thermoplastic elastomer (DUTEP), butyl rubber (BR), chlorocarboxylate polyethylene (CCPE), ethylene propylene rubber (EPR). To obtain a composition from these polymers, their mixture compatibility was first determined using …
Published in International Journal of Metallurgy and Alloys · Vol. 12, Issue 1, 2026 · pp. 44–56 Read article
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Major Analytical Problems in Current Pharmaceutical Drug Products
Abstract: Substances of pharmaceutical drug products go through thorough analyses to check the safety, efficacy as well as the quality of the final product. There are a number of shortcomings even though much has been done in the analytical methods used in recalls. Such challenges are those concerning method validation, sensitivity, specificity, reproducibility, and regulation. This article on major analytical problems in current pharmaceutical drug products outlines major limitations in the …
Published in International Journal of Analytical and Applied Chemistry · Vol. 11, Issue 1, 2025 · pp. 29–39 Read article
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Nanoelectronics, Nanoparticles and Nanotechnology in Treatment of Psychological Disorders
Abstract: Despite significant advancements in neuroscience, our understanding of brain functionality is far from complete, and ongoing research and testing are crucial for expanding our knowledge. With its billions of neurons and sophisticated neural networks, the brain is incredibly complicated, and scientists are always trying to find solutions for these problems. Here are a few reasons why continued research in the field of brain functionality is essential: The human brain is …
Published in International Journal of Environmental Chemistry · Vol. 10, Issue 1, 2024 · pp. 1–18 Read article
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General and Organic Chemistry Laboratory Experiments for Science , Pre-medical, and Pharmacy studentsChapter IV: Identification and Purification of Organic Compounds
Abstract: In order to identify an organic compound, a chemist needs to apply the suitable technique, depending on the compound state. Accordingly, melting point identification is applied for solids, boiling point for liquids, and sublimation for some compounds which have the tendency to sublime. On the other hand, When an organic compound is isolated from its natural source such as plants, it can be contaminated with some other undesirable compounds, called …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 1, 2026 · pp. 43–59 Read article
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Originative Approaches in Powder Formulation for Enhanced Therapeutic Efficacy
Abstract: Powder formulation is a cornerstone in the pharmaceutical industry, playing a vital role in improving drug efficacy and ensuring optimal therapeutic outcomes. However, traditional formulation methods often face significant challenges, such as poor solubility and low bioavailability, which can limit the effectiveness of many drugs. To address these issues, innovative strategies have emerged, including amorphous solid dispersions (ASDs), nanotechnology, and advanced manufacturing techniques like spray drying and hot melt etrusion. …
Published in International journal of Nanobiotechnology · Vol. 11, Issue 1, 2025 · pp. 1–10 Read article
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PHYSICOCHEMICAL PROPERTIES OF BROWNTOP MILLET AND EVALUATION OF ITS SUITABILITY IN PRODUCT FORMULATION
Abstract: The present study aims to investigate the physicochemical properties of Browntop millet, comparing it with refined wheat flour and evaluation of its suitability in product formulation. The proximate composition (moisture, ash, protein, fat and crude fiber) and functional properties (solubility, swelling power, water absorption capacity, oil absorption capacity andbulk density) were studied using AACC standard methods. The product bread was formulated by replacement of refined wheat flour of different levels …
Published in International Journal of Industrial Biotechnology and Biomaterials · Vol. 9, Issue 1, 2023 · pp. 18–27 Read article
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Microstructure and Mechanical Behavior of Microalloyed Forging Steels
Abstract: The microalloyed (MA) forging steels have been developed over the past several decades and they are gradually employed in the high-performance applications in many structural, automotive, and numerous engineering applications. The principle of microalloying contents in the Fe–C alloy system, thereby preferably combined with different mechanical, heat treatment, and microalloying solubility control the precipitation behaviors that lead to enormous opportunities to develop a new generation of high strength low alloy …
Published in International Journal of Metallurgy and Alloys · Vol. 11, Issue 2, 2025 · pp. 1–14 Read article
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Exploring the Boundless Applications of Chitosan: From Biomedical Marvel to Environmental Saviour
Abstract: Chitosan has attracted much interest because of its versatile properties and possible numerous usages in diversified industrial applications. Chitosan is having poor solubility in neutral and basic media and this is limiting its use. Chitosan is not a single polymer and do not have a defined structure. Chitosan is family of molecules with different composition, size & monomer units’ distribution and these characteristics have effect on the biological & technological …
Published in International Journal of Analytical and Applied Chemistry · Vol. 10, Issue 1, 2024 · pp. 1–9 Read article
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Recent Trends in Production, Characterization, and Utilization of Fungal Chitosan
Abstract: Chitosan is the second most abundant biopolymer in nature after cellulose that can be extracted from marine sources, as well as from agricultural waste products such as mushrooms or other fungal sources following chitin deacetylation. The consistent production of these glycans by fungi is unaffected by seasonal changes, allowing for precise process control. This results in a more consistent quality of the final product. Currently, crustacean shells and other marine …
Published in International Journal of Industrial Biotechnology and Biomaterials · Vol. 10, Issue 1, 2024 · pp. 23–31 Read article
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Modeling Fly Ash and Alccofine Partial Replacement of Concrete Density for High Strength Development
Abstract: This paper monitor the development of density from concrete model partially replaced cement with alccofine and fly ash, the study were generated applying modeling techniques, this concept were adopted to detail the influence of other concrete properties that influenced the growth rate of concrete density generated from such model concrete. Linear influences were observed in all the figures, the study observed variations of growth rate in the study, these are …
Published in International Journal of Sustainable Building Technology · Vol. 3, Issue 1, 2020 · pp. 29–48 Read article
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Efficient Use of Seriwaste for the qualitative Improvement in the Protein Contents of Black Soldier Fly (BSF), Hermetia illucens (L).
Abstract: Attempt deals with rearing of Black Soldier Fly (BSF), Hermetia illucens (L) reared on Excreta of Silkworm Larvae, Litter of mulberry leaves in rearing bed, dead larvae and dead pupae of Silkworm. The larval weight of BSF of the control group (Reared on Poultry Feed), first group (reared on Excreta of Silkworm), second group (reared on Litter of mulberry leaves in rearing bed of Silkworm Larvae), third group (reared on …
Published in International Journal of Animal Biotechnology and Applications · Vol. 9, Issue 1, 2023 · pp. 10–20 Read article
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Green Synthesis, Characterization and Antimicrobial Studies of Ni(II) and Cu(II) Schiff Base Complexes
Abstract: Solvent-assisted mechanochemical reaction was used to synthesize new transition metal complexes of Ni(II) and Cu(II) with Schiff base ligand (H2L) obtained from condensation of 2-hydroxy-1- napthaldehyde with 2 aminobenzimidazole. Melting point/decomposition temperature, solubility test, FT-IR, powder x-ray analysis, conductivity measurement, magnetic susceptibility, elemental microanalysis, and UV/VIS spectral investigations were used to characterize the Schiff base and complexes. The complexes are of varied colours and have sharp melting points, and they …
Published in International Journal of Green Chemistry · Vol. 8, Issue 1, 2022 · pp. 9–18 Read article
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Enhanced Recovery by Hydrotropes in Oxidized Coal Flotation
Abstract: AbstractSo far flotation proved its best in improving the concentration of low grade fines by recovering the maximum with the use of advanced flotation reagents. In this context we propose the process optimization with the use of hydrotropes as activators in the coal flotation process. It is observed that sodium benzoate a known hydrotrope helped in increasing the recovery of the concentrate percent from 12.8% at plant condition to 31% …
Published in International Journal of Renewable Energy and its Commercialization · Vol. 7, Issue 1, 2021 · pp. 19–23 Read article