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17 articles for “bioavailability”
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A Review Paper on Novel Lipid Nanoparticles for Enhanced Bioavailability of Bioactive Compounds in Breast Cancer Cell Lines
Abstract: Most bioactive compounds from natural products are heavily relied on drug development due to their biological, chemical and pharmacological properties. Some compounds exhibiting anticancer properties have also been reported. However, they present a challenge in achieving the effective absorption and delivery in the body. This is due to minimal bioavailability, fluctuation of plasma drug concentration, low tolerance, first-pass effect which leads to less desired efficacy. Therefore, this calls for an …
Published in International Journal of Composite and Constituent Materials · Vol. 10, Issue 1, 2024 · pp. 1–9 Read article
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Nanoparticles for Broiler Nutrition: Enhancing Growth, Feed Efficiency, Health, and Welfare of the Broiler Chicken
Abstract: Nanotechnology offers transformative potential for broiler nutrition by enabling enhanced nutrient delivery, efficiency, and health outcomes in poultry production. This review explores the applications, mechanisms, and impacts of incorporating nanoparticles, such as nano-minerals (e.g., zinc, selenium, and copper), nano-encapsulated bioactives, and other functional nano-additives, into broiler diets. Nanoparticles, owing to their increased surface area and enhanced bioavailability, have shown promise in improving nutrient absorption, promoting immune function, and supporting overall …
Published in International Journal of Nanomaterials and Nanostructures · Vol. 11, Issue 1, 2025 · pp. 32–43 Read article
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The Impact of Phytohormones on Human Metabolism and Wellbeing
Abstract: Phytohormones, or plant hormones, are vital organic compounds that regulate plant growth, development, and environmental responses. Recent research has shown that phytohormones like auxins, cytokinin, gibberellins, abscisic acid (ABA), ethylene, brassinosteroids, jasmonates, and salicylic acid may also positively impact human metabolism and overall health. Humans are exposed to these hormones primarily through the consumption of fruits, vegetables, and grains, and emerging studies suggest they may influence human metabolic pathways. This …
Published in International Journal of Plant Biotechnology · Vol. 10, Issue 2, 2024 · pp. 37–48 Read article
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Originative Approaches in Powder Formulation for Enhanced Therapeutic Efficacy
Abstract: Powder formulation is a cornerstone in the pharmaceutical industry, playing a vital role in improving drug efficacy and ensuring optimal therapeutic outcomes. However, traditional formulation methods often face significant challenges, such as poor solubility and low bioavailability, which can limit the effectiveness of many drugs. To address these issues, innovative strategies have emerged, including amorphous solid dispersions (ASDs), nanotechnology, and advanced manufacturing techniques like spray drying and hot melt etrusion. …
Published in International journal of Nanobiotechnology · Vol. 11, Issue 1, 2025 · pp. 1–10 Read article
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Establishment of a Sensitive LC-MS Method for Pharmacokinetic Evaluation of Decitabine and Cedazuridie in Rat Plasma
Abstract: A simple, rapid, and highly sensitive liquid chromatography–mass spectrometry (LC–MS) method was successfully developed and validated for the simultaneous determination of Decitabine and Cedazuridine in plasma matrices. The method demonstrated excellent linearity across the selected calibration range, with correlation coefficients (R²) consistently exceeding 0.999 for both analytes, indicating strong analytical performance. Method validation was carried out in accordance with ICH Q2(R2) and US FDA bioanalytical method validation guidelines, ensuring compliance …
Published in International Journal of Green Chemistry · Vol. 12, Issue 1, 2026 · pp. 34–42 Read article
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Establishment of a Sensitive LC-MS Method for Pharmacokinetic Evaluation of Decitabine and Cedazuridie in Rat Plasma
Abstract: Abstract A simple, rapid, and highly sensitive liquid chromatography–mass spectrometry (LC–MS) method was successfully developed and validated for the simultaneous determination of Decitabine and Cedazuridine in plasma matrices. The method demonstrated excellent linearity across the selected calibration range, with correlation coefficients (R²) consistently exceeding 0.999 for both analytes, indicating strong analytical performance. Method validation was carried out in accordance with ICH Q2(R2) and US FDA bioanalytical method validation guidelines, ensuring …
Published in International Journal of Green Chemistry · Vol. 12, Issue 1, 2026 · pp. 34–42 Read article
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Analytical Evaluation of heavy metals in eyeshadows: A Risk assessment and Implications for Public Health Regulatory Reforms in Nigeria
Abstract: This study employs advanced analytical techniques to assess heavy metal contamination (Pb, Cd, Cr, Ni, Zn) in 18 commercially available eyeshadow products (local and imported) from Owerri Metropolis, Nigeria. Quantification was conducted using atomic absorption spectroscopy (AAS), while risk evaluations incorporated chemometric modeling approaches. Results revealed significant contamination in locally manufactured brands, particularly those containing calabash chalk (Nzu) as a base ingredient. Lead and nickel concentrations reached 166.58 ± 6.5 …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 1, 2026 Read article
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How Heavy Metal Minerals Affect the Quality of Soil and Groundwater
Abstract: Heavy metal minerals polluting soil and groundwater is becoming a major environmental issue because these components are not biodegradable and last a long time. This study examines the degree to which heavy metals, including lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), and chromium (Cr), affect the chemical and physical characteristics of soil and groundwater in regions impacted by industrial, agricultural, and mining operations. Soil and water samples were obtained …
Published in International Journal of Environmental Chemistry · Vol. 11, Issue 2, 2025 · pp. 9–20 Read article
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Nanomaterials in Modern Medicine: Synthesis,Applications, and Future Prospects
Abstract: Nanomaterials have significantly transformed the biomedical landscape, offering novelsolutions for diagnosis, treatment, and disease prevention. Their distinct physicochemicalcharacteristics such as a high surface area-to-volume ratio, tunable surface chemistry, andimproved bioavailability enable precise interactions with biological systems at the molecularlevel. This review presents a comprehensive examination of the synthesis methods andcharacterisation techniques employed to develop biomedical-grade nanomaterials, highlightingtheir structural and functional optimisation for clinical applications. Key areas of applicationdiscussed include targeted …
Published in International Journal of Nanomaterials and Nanostructures · Vol. 11, Issue 2, 2025 Read article
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Turmeric and Its Mechanisms in Aging and Associated Conditions
Abstract: A gradual deterioration in physiological processes and heightened vulnerability to illnesses are hallmarks of aging, an unavoidable biological process. Turmeric (Curcuma longa), a staple in traditional medicine, has gained recognition for its role in mitigating the effects of aging and age-associated conditions. The therapeutic potential of turmeric is largely attributed to curcumin, its primary bioactive compound, which exhibits diverse pharmacological properties. Curcumin’s antioxidative capacity combats oxidative stress, a major driver …
Published in International Journal of Plant Biotechnology · Vol. 11, Issue 1, 2025 · pp. 34–41 Read article
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Nanoparticle-Based Drug Delivery System: A Review Of Recent Development And Challenges In Malaria
Abstract: Malaria remains a global health challenge despite extensive efforts in prevention and treatment. Prompt diagnosis and effective treatment are critical for eradication efforts, yet resistance to current therapeutic drugs, particularly in Plasmodium falciparum and Plasmodium vivax, poses a major obstacle. Traditional antimalarial such as quinine, chloroquine, and artemisinin-based combination therapies have been widely used, but their effectiveness is increasingly compromised by resistance and pharmacokinetic limitations. Many antimalarial drugs suffer from …
Published in International journal of Nanobiotechnology · Vol. 11, Issue 1, 2025 Read article
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Role of Human Carboxylesterase’s in Xenobiotics Metabolism
Abstract: According to one definition, xenobiotics are alien compounds that interfere with an organism's natural metabolism. Many xenobiotics can have a number of harmful effects if they don't have metabolism. There are several phase 1 metabolizing enzymes of xenobiotics which have capability to detoxify the toxic compounds. Several important metabolic detoxication enzymes are presented, including the mammalian microsomal cytochrome Carboxylesterases. Mammalian carboxyleterases are key enzymes from the serine hydrolase enzyme. Carboxylesterases …
Published in International Journal of Chemical Engineering and Processing · Vol. 11, Issue 1, 2025 · pp. 13–22 Read article
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A Comparative Study of Intravenous Paracetamol and Intravenous Diclofenac for Post-operative Pain Relief
Abstract: Despite advancements reducing mortality rates, adverse effects such as pain, nausea, and vomiting remain prevalent and can hinder recovery. Pain is now considered the fifth vital sign, as defined by the International Association for the Study of Pain, and inadequate pain management can result in prolonged hospital stays, increased drug use, and delayed recovery. Effective postoperative pain control is crucial in preventing respiratory complications and facilitating early discharge and return …
Published in International Journal of Analytical and Applied Chemistry · Vol. 11, Issue 1, 2025 · pp. 50–56 Read article
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Royal Jelly: A Brief Review of Nano and Micro Carriers and Potential Applications
Abstract: Royal Jelly, a bioactive substance known for its rich composition of proteins, lipids, and minerals, possesses significant antioxidant, antimicrobial, and anti-inflammatory properties. However, its instability in the presence of light, heat, and oxygen limits its practical applications. Recent advancements in nanotechnology, mainly using nanoparticles combined with microencapsulation techniques, have shown promise in enhancing royal jelly’s stability, bioavailability, and controlled release. This brief review explores encapsulated royal jelly’s biological effects and …
Published in International Journal of Environmental Chemistry · Vol. 11, Issue 1, 2025 · pp. 34–48 Read article
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Nanocapsules Applied in Pharmaceutical Delivery Systems
Abstract: Nanocapsules, which are minute vesicles composed of a parent material shielded by a polymer casing to encase the drug in the nucleus while regulating the drug’s dispensation and targeting capacity, represent a ground-breaking advancement in the realm of pharmaceuticals. The purpose behind the creation of nanocapsules is to enhance their efficiency and functionality by leveraging various methodologies like polymerization, solvent diffusion, dialysis, and supercritical fluid technology. These nanocapsules introduce a …
Published in International journal of Nanobiotechnology · Vol. 10, Issue 2, 2024 · pp. 1–10 Read article
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Review Article on: Nanoemulsion based intranasal drug delivery to Brain
Abstract: The bloodbrain barrier (BBB) controls and restricts the entry of therapeutic medications because it plays a critical role in protecting the brain from toxins.Nasal medicine administration allows for immediate drug delivery into the brain through the nose-to brain pathway.avoiding both the first pass impact and the blood-brain barrier. Various novel and promising formulation approaches have been explored for drug targeting to the brain by nasal administration. Nanoemulsions have the potential …
Published in International journal of Nanobiotechnology · Vol. 10, Issue 1, 2024 · pp. 17–24 Read article
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Automated Diagnosis and Drug Delivery System for Colon Cancer Using Biosensors and Nanostructures
Abstract: Colorectal cancer stands as a significant global health challenge, necessitating innovative approaches for early detection and effective treatment. This paper presents a novel framework for addressing this challenge by integrating biosensors with nano materials and nano structures to create an automated system for colon cancer diagnosis and treatment. The proposed system leverages the unique properties of biosensors for real-time disease detection and the advanced capabilities of nano materials and nano …
Published in International Journal of Nanomaterials and Nanostructures · Vol. 10, Issue 1, 2024 · pp. 10–23 Read article