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4 articles for “binding sites”
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Isocoreopsin and Glycogen Phosphorylase – An in-silico Interaction Study: A New Way to Tackle Type 2 Diabetes (T2D)†
Abstract: The activity of glycogen phosphorylase (GP) plays a crucial role in regulating glycogen metabolism, and its excessive activity has been closely linked to the pathogenesis of metabolic disorders, such as type 2 diabetes (T2D). Therefore, targeting GP inhibition has emerged as a significant therapeutic strategy for managing this disease. Current research focuses on the discovery and development of novel small molecules capable of suppressing GP activity. Among these, flavonoids have …
Published in International Journal of Environmental Chemistry · Vol. 11, Issue 1, 2025 · pp. 76–80 Read article
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In Vitro Evaluation of Bioremediation Capacity of a Commercial Probiotic, Bacillus clausii, for Chromium (VI) and Lead (II) Toxicity
Abstract: Heavy metals cause disastrous effects on any living organisms. Probiotics have the ability to reduce metal toxicity. Commercial probiotics having bioremediation capacity can use these bacteria as an alternative to conventional remediation methods. The bioaccumulation of heavy metals including chromium (VI) (Cr [VI]) and lead (II) (Pb [II]) causes fatal toxicity in humans. Some naturally occurring bacterial species, such as Bacillus and Pseudomonas, contribute their role in bioremediation of these …
Published in International Journal of Industrial Biotechnology and Biomaterials · Vol. 4, Issue 2, 2018 · pp. 1–16 Read article
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Spermmediated gene transfer revisited: optimizing delivery, integration, and germline transmissionin large animal models
Abstract: Spermmediated gene transfer (SMGT) exploits the natural role of spermatozoa as DNA vectors to deliver exogenous genetic material to oocytes, potentially enabling economical production of transgenic large animals without complex embryo micromanipulation (1). Early proofofconcept studies established that mammalian sperm can bind, internalize, and protect exogenous DNA, leading to integration, expression, and germline transmission in various species, including pigs (24). Subsequent mechanistic work has challenged the traditional view of sperm …
Published in International Journal of Animal Biotechnology and Applications · Vol. 12, Issue 1, 2026 Read article
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A Comparative Study of Intravenous Paracetamol and Intravenous Diclofenac for Post-operative Pain Relief
Abstract: Despite advancements reducing mortality rates, adverse effects such as pain, nausea, and vomiting remain prevalent and can hinder recovery. Pain is now considered the fifth vital sign, as defined by the International Association for the Study of Pain, and inadequate pain management can result in prolonged hospital stays, increased drug use, and delayed recovery. Effective postoperative pain control is crucial in preventing respiratory complications and facilitating early discharge and return …
Published in International Journal of Analytical and Applied Chemistry · Vol. 11, Issue 1, 2025 · pp. 50–56 Read article