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2 articles for “Xenotransplantation”
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Biotechnological Advancements in Animal Organ Transplantation and Xenotransplantation
Abstract: Biotechnological advancements in the fields of animal organ transplantation and xenotransplantation have made significant strides over the past few decades. These advancements offer promising solutions to the worldwide shortage of organs needed for transplants. Xenotransplantation – transplanting organs or tissues from animals to humans – shows great potential in tackling this problem. Recent breakthroughs in biotechnology, such as genetic engineering, immune suppression techniques, and improved organ preservation methods, have brought …
Published in International Journal of Animal Biotechnology and Applications · Vol. 11, Issue 1, 2025 · pp. 6–10 Read article
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Spermmediated gene transfer revisited: optimizing delivery, integration, and germline transmissionin large animal models
Abstract: Spermmediated gene transfer (SMGT) exploits the natural role of spermatozoa as DNA vectors to deliver exogenous genetic material to oocytes, potentially enabling economical production of transgenic large animals without complex embryo micromanipulation (1). Early proofofconcept studies established that mammalian sperm can bind, internalize, and protect exogenous DNA, leading to integration, expression, and germline transmission in various species, including pigs (24). Subsequent mechanistic work has challenged the traditional view of sperm …
Published in International Journal of Animal Biotechnology and Applications · Vol. 12, Issue 1, 2026 Read article