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20 articles for “Therapeutic agents”
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A Review Paper on Novel Lipid Nanoparticles for Enhanced Bioavailability of Bioactive Compounds in Breast Cancer Cell Lines
Abstract: Most bioactive compounds from natural products are heavily relied on drug development due to their biological, chemical and pharmacological properties. Some compounds exhibiting anticancer properties have also been reported. However, they present a challenge in achieving the effective absorption and delivery in the body. This is due to minimal bioavailability, fluctuation of plasma drug concentration, low tolerance, first-pass effect which leads to less desired efficacy. Therefore, this calls for an …
Published in International Journal of Composite and Constituent Materials · Vol. 10, Issue 1, 2024 · pp. 1–9 Read article
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Optimization Strategies Towards Enhanced Production of Microbial Surfactants for Diverse Industrial Applications: A Futuristic Approach
Abstract: Chemical or synthetic surfactants being employed in numerous industries pose significant environmental hazards due to their persistence in the environment and potential toxicity to aquatic life. Biosurfactants are low-molecular-weight surface-active compounds that offer a promising alternative to surfactants owing to their less toxicity, biodegradability and biocompatibility nature. They are derived from a variety of natural sources, including bacteria, fungi, and plants. In recent years, there has been a surge in …
Published in International Journal of Industrial Biotechnology and Biomaterials · Vol. 10, Issue 1, 2024 · pp. 11–22 Read article
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Nanotechnology as a new perspective in Regenerative Medicine
Abstract: The introduction of nanotechnology has brought a transformation in medical technology frommicro fluidics to nanomedicine. As nanotechnology is multidisciplinary, it promotes severalscience and technology. Importantly, strategies and principles of physic and nanotechnologyas new perspective in nanomedicine, plays a pivotal role in personal medicine, precisionmedicine, and regenerative medicine. Herein, look toward the strategies of physics includingelectric stimulations, magnetism, and electro mechanics in shaping the regenerative medicine.Moreover, the potential of nanotechnology in …
Published in International journal of Nanobiotechnology · Vol. 11, Issue 2, 2025 Read article
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Synthesis and Evaluation of Antifungal Properties of 2-((4-((6phenylimidazo[2,1-b][1,3,4]thiadiazole-2-yl)methoxy)phenoxy)methyl)-6-phenylimidazo[2,1-b][1,3,4] thiadiazole Derived from Hydroquinone
Abstract: Thiadiazole, a heterocyclic core, has garnered significant interest from chemists seeking novel therapeutic agents. The synthetic route for the target compounds is depicted in Scheme 1. The compounds were synthesized with favorable yields through the condensation of hydroquinone with various organic reagents. They underwent physical characterization and were analyzed using spectroscopic methods, including infrared (FTIR) and NMR (1H, 13C) spectroscopy. The FT-IR spectrum of the product exhibited a ν(C=N) absorption …
Published in International Journal of Environmental Chemistry · Vol. 12, Issue 1, 2026 · pp. 76–82 Read article
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A Comprehensive Review on Withania somnifera Species
Abstract: Withania somnifera (L.) Dunal, often referred to as Ashwagandha or Indian ginseng, is a renownedmedicinal herb widely utilized in traditional medical practices, especially Ayurveda, and it belongs tothe Solanaceae family. The plant has attracted considerable scientific interest because of its wide rangeof pharmacological effects and therapeutic possibilities. Different sections of this plant, particularly theroots and leaves, possess bioactive components that enhance its therapeutic properties. Many experimental and clinical studies have …
Published in International Journal of Industrial Biotechnology and Biomaterials · Vol. 12, Issue 1, 2026 Read article
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Factors Attributed to Antimicrobial Activity of Honey and Its Analysis on Some Selected Microorganisms
Abstract: To summaries, we believe that honey is an intriguing and promising alternative to traditional antibiotics and that it should be taken more seriously as a therapeutic agent. Honey is widely regarded as the world's oldest medicine, and for good reason. Since time immemorial, it is believed to heal wounds along with antibiotic. The immunomodulatory present in it is also known to give proper wound healing. The antibiotic in many honeys …
Published in International Journal of Analytical and Applied Chemistry · Vol. 7, Issue 2, 2021 · pp. 37–43 Read article
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Advancement of Poly-(ADP – Ribose) Polymerase (PARP) Inhibitors in Cancer Progression and Treatment
Abstract: DNA repair mechanisms are the most common and potential targets in cancer treatment. PARP enzymes play a crucial role in detection of DNA damage and its repair and also in apoptosis. Detailed knowledge of these mechanisms leads to the development of poly-(ADP-Ribose) polymerase (PARP) inhibitors as vigorous anticancer drugs with specific action. PARP inhibitors can selectivity kill tumours with deficiencies in DNA repair proteins like BRCA1/2, exploiting synthetic lethality concept. …
Published in International Journal of Animal Biotechnology and Applications · Vol. 1, Issue 1, 2015 Read article
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The Impact of Phytohormones on Human Metabolism and Wellbeing
Abstract: Phytohormones, or plant hormones, are vital organic compounds that regulate plant growth, development, and environmental responses. Recent research has shown that phytohormones like auxins, cytokinin, gibberellins, abscisic acid (ABA), ethylene, brassinosteroids, jasmonates, and salicylic acid may also positively impact human metabolism and overall health. Humans are exposed to these hormones primarily through the consumption of fruits, vegetables, and grains, and emerging studies suggest they may influence human metabolic pathways. This …
Published in International Journal of Plant Biotechnology · Vol. 10, Issue 2, 2024 · pp. 37–48 Read article
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Evaluation of Cytotoxic Activity of Cestrum nocturnum Leaves Extract against A549 Cell Line using MTT Assay
Abstract: Cancer remains a major global cause of death, necessitating ongoing research for effective treatments. Traditional herbal medicine is being explored for novel anti-cancer compounds. This study investigates the cytotoxic effects of Cestrum nocturnum ethanolic extract on A549 lung cancer cells, a type of non-small cell lung cancer (NSCLC). NSCLC is a significant health concern in India, affecting even non-smokers. Cestrum nocturnum, known as Night-blooming jasmine, has shown promise in inhibiting …
Published in International Journal of Plant Biotechnology · Vol. 9, Issue 2, 2023 · pp. 29–33 Read article
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Compliance to Therapeutic Regimen Among Patients with Epilepsy
Abstract: Introduction: The public health of India is increasingly burdened by chronic diseases. Epilepsy is one among them which change its faces with changing demographics. It is a chronic condition requiring careful long-term management. The treatment is complex involving classification, diagnosis, selection & monitoring of the appropriate antiepileptic agent, and evaluation of the chosen drug's side effects & drug interactions. Hence patient compliance and identification of the factors affecting patient compliance …
Published in International Journal of Medical Surgical Nursing · Vol. 2, Issue 2, 2019 · pp. 28–33 Read article
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Role of Human Carboxylesterase’s in Xenobiotics Metabolism
Abstract: According to one definition, xenobiotics are alien compounds that interfere with an organism's natural metabolism. Many xenobiotics can have a number of harmful effects if they don't have metabolism. There are several phase 1 metabolizing enzymes of xenobiotics which have capability to detoxify the toxic compounds. Several important metabolic detoxication enzymes are presented, including the mammalian microsomal cytochrome Carboxylesterases. Mammalian carboxyleterases are key enzymes from the serine hydrolase enzyme. Carboxylesterases …
Published in International Journal of Chemical Engineering and Processing · Vol. 11, Issue 1, 2025 · pp. 13–22 Read article
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Nanomaterials in Modern Medicine: Synthesis,Applications, and Future Prospects
Abstract: Nanomaterials have significantly transformed the biomedical landscape, offering novelsolutions for diagnosis, treatment, and disease prevention. Their distinct physicochemicalcharacteristics such as a high surface area-to-volume ratio, tunable surface chemistry, andimproved bioavailability enable precise interactions with biological systems at the molecularlevel. This review presents a comprehensive examination of the synthesis methods andcharacterisation techniques employed to develop biomedical-grade nanomaterials, highlightingtheir structural and functional optimisation for clinical applications. Key areas of applicationdiscussed include targeted …
Published in International Journal of Nanomaterials and Nanostructures · Vol. 11, Issue 2, 2025 Read article
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Xerostomia and Salivary Gland Hypofunction: From Pathophysiology to Nanotechnology‑Enabled Regenerative Therapies
Abstract: Xerostomia, the subjective sensation of oral dryness, is a common yet frequently underrecognized condition with multifactorial etiology and substantial consequences for oral and systemic health. Salivary gland hypofunction underlies many, but not all, cases and may result from medication use, head and neck radiotherapy, autoimmune disease, systemic illnesses, or age-related and hormonal changes. Persistent xerostomia impairs mastication, swallowing, speech, taste, and sleep, and predisposes to dental caries, periodontal disease, oral …
Published in International journal of Nanobiotechnology · Vol. 12, Issue 1, 2026 · pp. 1–27 Read article
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Exploring Fecal Microbiota Transplantation: A Comprehensive Overview
Abstract: Fecal Microbiota Transplantation (FMT) has become a revolutionary treatment for rebalancing the gut microbiome, especially in patients with recurrent Clostridioides difficile infection (CDI). This comprehensive review delves into the evolution, methodologies, clinical applications, and future directions of FMT. Initially developed as a solution to combat severe gastrointestinal dysbiosis, FMT has demonstrated significant efficacy in treating CDI, with cure rates surpassing 80% in numerous studies. The review examines various FMT delivery …
Published in International Journal of Immunological Nursing · Vol. 10, Issue 2, 2024 · pp. 19–24 Read article
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Nanotechnology Era: Comprehensive Study of Magnetic ZnxFe2–xO3 Nanoparticles for Enhanced Treatment of Cancer and Infectious Disease
Abstract: In the contemporary world, scientists, technologists, and medical professionals are able to transform the knowledge of nanotechnology to medical treatment. They have been struggling to eradicate or reduce the risk effects of epidemic disease from the world. Such epidemic disease is challenging due to their vast replication, regeneration, hereditary case, genetic variations, and passages through genetic matter. For this reason, this research is focused on the biomedical application of ZnxFe2–xO3 …
Published in International journal of Nanobiotechnology · Vol. 10, Issue 2, 2024 · pp. 33–48 Read article
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Autoimmune Polyglandular Syndrome Type 1 (APS-1): A Rare Yet Crucial Condition to Recognize
Abstract: Autoimmune Polyglandular Syndrome Type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED), is a rare autosomal recessive disorder caused by mutations in the AIRE (Autoimmune Regulator) gene. This syndrome is characterized by a triad of chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenal insufficiency, although it can affect multiple other organ systems. APS-1 arises from a failure of central immune tolerance, resulting in autoimmunity against various endocrine and non-endocrine tissues. The …
Published in International Journal of Immunological Nursing · Vol. 11, Issue 1, 2025 Read article
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Recent Advances in Fused Heterocyclic Pyridine Compounds for Bioactive Anti-Inflammatory Drug Discovery
Abstract: Heterocyclic compounds, particularly those fused with pyridine rings, have emerged as promising candidates in the search for novel bioactive agents with anti-inflammatory properties. This review highlights recent advances in the discovery and development of fused heterocyclic pyridine compounds as potential anti-inflammatory drugs. The unique structural properties of fused heterocycles contribute to their ability to modulate key inflammatory pathways. By targeting specific molecular targets involved in inflammation, such as cytokines, enzymes, …
Published in International Journal of Chemical Separation Technology · Vol. 10, Issue 1, 2024 · pp. 1–7 Read article
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Nanotechnology-Enabled Non-Invasive Teeth Whitening: Safety,Efficacy, and Regulatory Perspectives with a Focus on India, Asia, and Developed Countries
Abstract: Demand for tooth whitening is growing worldwide, but conventional peroxide-based bleaching is associated with dentin hypersensitivity, enamel softening, and softtissue irritation, especially under repeated or high-concentration use. Nanotechnology offers a new class of non-invasive whitening strategies that aim to combine esthetic improvement with enamel protection and remineralization. Among these, nanohydroxyapatite (nanoHAP) toothpastes and gels have the most advanced evidence base; in vitro and in situ studies indicate that nanoHAP deposits …
Published in International Journal of Nanomaterials and Nanostructures · Vol. 12, Issue 1, 2026 Read article
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Nanotechnology-Enabled Non-Invasive Teeth Whitening: Safety, Efficacy, and Regulatory Perspectives with a Focus on India, Asia, and Developed Countries
Abstract: Demand for tooth whitening is growing worldwide, but conventional peroxide-based bleaching is associated with dentin hypersensitivity, enamel softening, and soft tissue irritation, especially under repeated or high-concentration use. Nanotechnology offers a new class of non-invasive whitening strategies that aim to combine esthetic improvement with enamel protection and remineralization. Among these, nanohydroxyapatite (nanoHAP) toothpastes and gels have the most advanced evidence base; in vitro and in situ studies indicate that nanoHAP …
Published in International Journal of Nanomaterials and Nanostructures · Vol. 12, Issue 1, 2026 Read article
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Nanoparticle-Based Drug Delivery System: A Review Of Recent Development And Challenges In Malaria
Abstract: Malaria remains a global health challenge despite extensive efforts in prevention and treatment. Prompt diagnosis and effective treatment are critical for eradication efforts, yet resistance to current therapeutic drugs, particularly in Plasmodium falciparum and Plasmodium vivax, poses a major obstacle. Traditional antimalarial such as quinine, chloroquine, and artemisinin-based combination therapies have been widely used, but their effectiveness is increasingly compromised by resistance and pharmacokinetic limitations. Many antimalarial drugs suffer from …
Published in International journal of Nanobiotechnology · Vol. 11, Issue 1, 2025 Read article