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10 articles for “Pharmacokinetics”
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Establishment of a Sensitive LC-MS Method for Pharmacokinetic Evaluation of Decitabine and Cedazuridie in Rat Plasma
Abstract: A simple, rapid, and highly sensitive liquid chromatography–mass spectrometry (LC–MS) method was successfully developed and validated for the simultaneous determination of Decitabine and Cedazuridine in plasma matrices. The method demonstrated excellent linearity across the selected calibration range, with correlation coefficients (R²) consistently exceeding 0.999 for both analytes, indicating strong analytical performance. Method validation was carried out in accordance with ICH Q2(R2) and US FDA bioanalytical method validation guidelines, ensuring compliance …
Published in International Journal of Green Chemistry · Vol. 12, Issue 1, 2026 · pp. 34–42 Read article
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Establishment of a Sensitive LC-MS Method for Pharmacokinetic Evaluation of Decitabine and Cedazuridie in Rat Plasma
Abstract: Abstract A simple, rapid, and highly sensitive liquid chromatography–mass spectrometry (LC–MS) method was successfully developed and validated for the simultaneous determination of Decitabine and Cedazuridine in plasma matrices. The method demonstrated excellent linearity across the selected calibration range, with correlation coefficients (R²) consistently exceeding 0.999 for both analytes, indicating strong analytical performance. Method validation was carried out in accordance with ICH Q2(R2) and US FDA bioanalytical method validation guidelines, ensuring …
Published in International Journal of Green Chemistry · Vol. 12, Issue 1, 2026 · pp. 34–42 Read article
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A Comparative Study of Intravenous Paracetamol and Intravenous Diclofenac for Post-operative Pain Relief
Abstract: Despite advancements reducing mortality rates, adverse effects such as pain, nausea, and vomiting remain prevalent and can hinder recovery. Pain is now considered the fifth vital sign, as defined by the International Association for the Study of Pain, and inadequate pain management can result in prolonged hospital stays, increased drug use, and delayed recovery. Effective postoperative pain control is crucial in preventing respiratory complications and facilitating early discharge and return …
Published in International Journal of Analytical and Applied Chemistry · Vol. 11, Issue 1, 2025 · pp. 50–56 Read article
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Postoperative Pain Management: Understanding the Role of NSAIDs and Analgesics
Abstract: Postoperative pain management is a critical aspect of clinical care, with a significant impact on patient recovery and quality of life. Among the pharmacological options available, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and acetaminophen (paracetamol) are widely utilized due to their distinct chemical properties and mechanisms of action. This study aims to evaluate and compare the efficacy of intravenous paracetamol (C₈H₉NO₂) and diclofenac (C₁₄H₁₁Cl₂NO₂) in postoperative analgesia, focusing on their pharmacokinetic profiles, …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 11, Issue 1, 2026 · pp. 36–42 Read article
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Safety, Toxicology, and Regulatory Science of CT Nano‐Contrast Agents in Radiology
Abstract: Nanoparticle-based contrast agents for X-ray computed tomography (CT) seek to overcome limitations of conventional iodinated small-molecule media but raise distinctive safety, toxicology, and regulatory science questions. Nano–bio-interactions specific to CT nanocontrast include reticuloendothelial system (RES) uptake, long-term hepatic and splenic retention, size-dependent renal versus hepatobiliary clearance, and potential immunogenicity and genotoxicity, all strongly influenced by particle composition, size, shape, surface charge, and coating chemistry. Robust preclinical evaluation requires harmonized in …
Published in International Journal of Applied Nanotechnology · Vol. 12, Issue 1, 2026 · pp. 36–47 Read article
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Molecular Docking of Catharanthus Roseus Bioactive Compounds of Targetinging Bovine Leukaemia Virus
Abstract: Therapeutic potential of Catharanthus roseus bioactive compounds as the 4PHO protein inhibitors, a pathogenetic determinative factor of BLV. This work describes the use of computational drug discovery approaches in estimating the interactions conducted between 40 phytocompounds of Catharanthus roseus and the 4PHO protein. Our work has determined the presence of Pamoic acid and Vindolinine hydrochloride as the optimal choice here. Pharmacokinetic screening exhibited drug-like properties to both the highly absorbed …
Published in International Journal of Animal Biotechnology and Applications · Vol. 11, Issue 2, 2025 · pp. 19–31 Read article
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Nanoparticle-Based Drug Delivery System: A Review Of Recent Development And Challenges In Malaria
Abstract: Malaria remains a global health challenge despite extensive efforts in prevention and treatment. Prompt diagnosis and effective treatment are critical for eradication efforts, yet resistance to current therapeutic drugs, particularly in Plasmodium falciparum and Plasmodium vivax, poses a major obstacle. Traditional antimalarial such as quinine, chloroquine, and artemisinin-based combination therapies have been widely used, but their effectiveness is increasingly compromised by resistance and pharmacokinetic limitations. Many antimalarial drugs suffer from …
Published in International journal of Nanobiotechnology · Vol. 11, Issue 1, 2025 Read article
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A Review Paper on Novel Lipid Nanoparticles for Enhanced Bioavailability of Bioactive Compounds in Breast Cancer Cell Lines
Abstract: Most bioactive compounds from natural products are heavily relied on drug development due to their biological, chemical and pharmacological properties. Some compounds exhibiting anticancer properties have also been reported. However, they present a challenge in achieving the effective absorption and delivery in the body. This is due to minimal bioavailability, fluctuation of plasma drug concentration, low tolerance, first-pass effect which leads to less desired efficacy. Therefore, this calls for an …
Published in International Journal of Composite and Constituent Materials · Vol. 10, Issue 1, 2024 · pp. 1–9 Read article
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Green Flora –Natural Missile to Treat Life Threaten Psoriasis
Abstract: Psoriasis is a life threatened disease caused by either genetic or other factor like like infection, increased number of t cell in body, populated environment, unsuitable and unpalatable food ingestion. near of 0.44-2.8% population in india is affected by psoriasis. allopathic medicine in the form of dosage form for internal administration and external application are available. these synthetic drug for psoriasis treatment are having side effect and adverse effect the …
Published in International Journal of Green Chemistry · Vol. 9, Issue 2, 2023 · pp. 1–14 Read article
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REVIEW ON PREPARATION METHODS & APPLICATION FIELDS OF OXADIAZOLE
Abstract: This review displays oxadiazole (five-ring) that is of great importance in the fields of pharmacy, medicine, and field of coordinated chemistry and as reagents to estimate the small quantities of trace elements and minerals. Oxadiazole is a primary role and as a basic substance for many pharmacokinetic compounds such as antimalarial drugs, anti- bacterial, and cancerous tumors. This survey described several approach for preparation methods of oxadizole with their applications …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 6, Issue 1, 2020 · pp. 49–60 Read article