Search
2 articles for “Multisystem autoimmunity”
-
Autoimmune Polyglandular Syndrome Type 1 (APS-1): A Rare Yet Crucial Condition to Recognize
Abstract: Autoimmune Polyglandular Syndrome Type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED), is a rare autosomal recessive disorder caused by mutations in the AIRE (Autoimmune Regulator) gene. This syndrome is characterized by a triad of chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenal insufficiency, although it can affect multiple other organ systems. APS-1 arises from a failure of central immune tolerance, resulting in autoimmunity against various endocrine and non-endocrine tissues. The …
Published in International Journal of Immunological Nursing · Vol. 11, Issue 1, 2025 Read article
-
A Study on Autoimmune Diseases and Their Effects on Body Systems
Abstract: Autoimmune diseases are disorders in which the immune system mistakenly attacks the body’s own healthy cells, tissues, and organs instead of protecting them from harmful substances. This abnormal response results in inflammation, tissue injury, and impaired function of different organs. The purpose of this study is to present a general understanding of autoimmune disorders and explore their impact on multiple body systems, such as the musculoskeletal, nervous, endocrine, cardiovascular, and …
Published in International Journal of Immunological Nursing · Vol. 12, Issue 1, 2026 · pp. 22–26 Read article