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25 articles for “Medicinal chemistry”
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Brief Introduction to Medicinal Chemistry
Abstract: Medicinal chemistry is an interdisciplinary scientific field of chemistry which combines the applied and basic sciences. In simple words, medicinal chemistry is an interwoven science that combines the basics of chemistry, pharmacy, and drug discovery and designing. It comprises the discovery, development, identification, and interpretation of the mode of action of biologically active molecules and compounds at molecular level.
Published in International Journal of Analytical and Applied Chemistry · Vol. 2, Issue 2, 2016 · pp. 38–39 Read article
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Exploring Aptamer Applications in Analytical Chemistry, Medicine, and Food Industry.
Abstract: Many studies have been conducted and a large number of isolated aptamers for different targets have been used since Ellington and Gold's independent description of aptamer and its in vitro selection method, known as SELEX, in 1990. With excellent binding affinity and selectivity, aptamers can bind to a variety of targets, such as haptens, small organic molecules, inorganic compounds, and even entire cells. Currently, aptamers for a large variety of …
Published in International Journal of Energetic Materials · Vol. 9, Issue 1, 2023 · pp. 21–27 Read article
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Heterocyclic Oxadiazole Derivatives Through Various Spectroscopic Techniques as UV, IR.
Abstract: The study focuses on the synthesis, characterization, and analysis of heterocyclic oxadiazole derivatives using various spectroscopic techniques, including UV-visible (UV-Vis) spectroscopy and infrared (IR) spectroscopy. Oxadiazoles are a type of five-membered heterocyclic compounds with nitrogen and oxygen atoms. They are important in medical chemistry and materials research and show a wide range of biological activity. The synthesized oxadiazole derivatives were characterized through UV-Vis spectroscopy to investigate their electronic transitions and …
Published in International Journal of Analytical and Applied Chemistry · Vol. 10, Issue 1, 2024 · pp. 1–8 Read article
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Synthesis and Evaluation of Antimicrobial Activity of Some Heterocyclic Moieties of Pyrazole Derivatives
Abstract: In a successful trial to synthesize pyrazole derivatives, acetophenone was, first, reacted with phenylhydrazine producing the Schiffs’s base condensation product (E)-1-phenyl-2-(2-phenylethylidene) hydrazine 1. The application of Vilsmeier Haack’s reaction on this product afforded the cyclization product (1,3-diphenyl-1H-pyrazole-4-carbaldehyde 2 as a pyrazole derivative in good yield percentage. The treatment of (1,3-diphenyl-1H-pyrazole-4-carbaldehyde (2) with acetophenone results in the formation of another pyrazole derivative (3), having a chalcone moiety.The chemical structure of newly …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 10, Issue 1, 2025 · pp. 26–36 Read article
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Synthetic Studies on Fused Benzodiazepines: A Class of Medicinally Privileged Heterocycles
Abstract: 1,4-Benzodiazepine is an important nitrogen heterocyclic scaffold because of its presence in various natural products, drugs and biologically active molecules. Henceforth, it is also known as privileged heterocycle in the field of medicinal to synthetic organic chemistry. Reactions towards the synthesis of five- and six- membered heterocycles are very easy and facile. On the other hand, synthesis of medium ring heterocycles is more difficult because of the thermodynamic limitations. Thus …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 4, Issue 2, 2018 · pp. 44–59 Read article
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Mechanistic Insights into Solvent-Controlled Stepwise and Concerted Cycloadditions of the Propadienyl Cation with Oxoamides: A DFT Study
Abstract: AbstractOxazoles constitute an important class of heterocycles with widespread applications in medicinal chemistry and materials science, yet the mechanistic features governing their formation via cationic cycloaddition reactions remain incompletely understood. In this work, we present a comprehensive density functional theory (DFT) investigation into the reaction between the propadienyl cation and oxoamides as a model system for oxazole ring formation. Using the CAM-B3LYP/6–31+G(d,p) level of theory, we systematically compare gas-phase reactivity …
Published in International journal of Thermodynamics and Chemical Kinetics · Vol. 12, Issue 1, 2026 · pp. 8–17 Read article
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Nanotechnology in Refractory Materials: Innovations and Applications
Abstract: Nanotechnology has become a focal point of research across diverse scientific fields, including chemistry, medicine, materials science, and engineering. Its integration into refractory products has led to groundbreaking advancements in industries such as steel, glass, casting, and cement, particularly using nanomaterials like nanoparticles, nano additives, and nanostructured materials. This article provides an in-depth examination of the latest developments in monolithic refractories, focusing on how nanotechnology has enhanced their performance, durability, …
Published in International Journal of Metallurgy and Alloys · Vol. 10, Issue 1, 2024 · pp. 7–11 Read article
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REVIEW OF HETEROCYCLIC COMPOUNDS AND APPLICATION FOR SUSTAINABILITY
Abstract: Heterocyclic compounds constitute the most extensive and varied group among organic compounds. Today, there are many heterocyclic compounds that are known, and as a result of extensive synthetic research as well as their usefulness in synthetic processes, this number is steadily growing. Heterocyclic molecules play a pivotal role in numerous scientific fields, such as medicinal chemistry and biochemistry, highlighting the blurred boundaries between various chemical disciplines. Heterocyclic chemistry seamlessly extends …
Published in International Journal of Analytical and Applied Chemistry · Vol. 9, Issue 1, 2023 · pp. 49–54 Read article
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RECENT TRENDS IN APPLICATIONS OF NANOTECHNOLOGY
Abstract: The field of pharmaceutical and nanotechnology has been growing rapidly.This review will provide the recent advancement that in the field of nanotechnology .It will focus on the development of multifunctional particles for drug delivery. The current nanotechnology studies have been growing in chemistry and medicine because of applications of nanomaterials mainly in Chemical Engineering, Biochemistry, Genetics and Molecular Biology.
Published in International Journal of Applied Nanotechnology · Vol. 1, Issue 1-2, 2015 Read article
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Recent Trends in Applications of Nanotechnology
Abstract: The field of Pharmaceutical and Nanotechnology has been growing rapidly. This review will provide the recent advancement that in the field of Nanotechnology. It will focus on the development of multifunctional particles for drug delivery. The current Nanotechnology studies have been growing in Chemistry and Medicine because of applications of Nanomaterials mainly in Chemical Engineering, Biochemistry, Genetics and Molecular Biology. Keywords: Nanotechnology, genetics, drug delivery, nanocarriers
Published in International Journal of Nanomaterials and Nanostructures · Vol. 1, Issue 1, 2015 · pp. 33–36 Read article
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Synthesis and Evaluation of Antifungal Properties of 2-((4-((6phenylimidazo[2,1-b][1,3,4]thiadiazole-2-yl)methoxy)phenoxy)methyl)-6-phenylimidazo[2,1-b][1,3,4] thiadiazole Derived from Hydroquinone
Abstract: Thiadiazole, a heterocyclic core, has garnered significant interest from chemists seeking novel therapeutic agents. The synthetic route for the target compounds is depicted in Scheme 1. The compounds were synthesized with favorable yields through the condensation of hydroquinone with various organic reagents. They underwent physical characterization and were analyzed using spectroscopic methods, including infrared (FTIR) and NMR (1H, 13C) spectroscopy. The FT-IR spectrum of the product exhibited a ν(C=N) absorption …
Published in International Journal of Environmental Chemistry · Vol. 12, Issue 1, 2026 · pp. 76–82 Read article
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Chemistry of Mehandi (Henna): Natural Dyeing Mechanism, Composition, and Applications
Abstract: Mehandi (Henna), derived from the plant Lawsonia inermis, is one of the oldest natural dyes used for body art, hair coloring, and traditional medicinal applications. Beyond its cultural significance, henna represents an interesting example of applied organic chemistry, where naturally occurring molecules interact with biological tissues to produce long-lasting coloration. The primary coloring constituent of henna is Lawsone (2-hydroxy-1,4-naphthoquinone), a naphthoquinone compound responsible for the characteristic reddish-brown stain. When henna …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 2, 2026 · pp. 39–45 Read article
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REVIEW ON PREPARATION METHODS & APPLICATION FIELDS OF OXADIAZOLE
Abstract: This review displays oxadiazole (five-ring) that is of great importance in the fields of pharmacy, medicine, and field of coordinated chemistry and as reagents to estimate the small quantities of trace elements and minerals. Oxadiazole is a primary role and as a basic substance for many pharmacokinetic compounds such as antimalarial drugs, anti- bacterial, and cancerous tumors. This survey described several approach for preparation methods of oxadizole with their applications …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 6, Issue 1, 2020 · pp. 49–60 Read article
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Schemes of Trace Selenium Nanoparticles on Earth
Abstract: This article is written about resources of selenium compatible with dosage-wise recovery from nature. Selenium (Se) above trace is toxic to human beings. The plant is the source of Se based on differential stages in botanical ethics from various parts of plants. Selenium found in nature as selenite, selenite, selenides, and seleno-proteins in plants. Se nanospheres related to a size considered as of importance in industry and biology acts. Antimicrobial …
Published in International Journal of Chemical Separation Technology · Vol. 7, Issue 1, 2021 Read article
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Survey on Semicarbazide and Thiosemicarbazide Derivatives
Abstract: This review insurances around semicarbazide and thiosemicarbazide with derivatives throughpresentation of their preparation methods, reactions like cyclization processes. Thiosemicarbazonesand semicarbazones are an important class of ligands for the synthesis of transition metal complexeswith applications in medicine and electrochemistry, also in organic chemistry fields., Tumor is amalignant in addition invasive development or cancer, particularly of epithelium derivation, whichinclines to recur after erasure also may metastasize to other places. It befalls due …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 7, Issue 1, 2021 · pp. 51–57 Read article
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A Review Status on Application of Separation Techniques in Daily Life
Abstract: In chemistry and related fields, a unit operation is the basic step in a process. Unit operations involve a physical change or chemical transformation such as separation, crystallization, evaporation, filtration, polymerization, isomerization, and other reactions. Researchers have developed economic ways of using materials and energy. Chemical engineers use chemistry and engineering to turn raw materials into usable products, such as medicine, petrochemicals and plastics on a large-scale industrial setting. They …
Published in International Journal of Chemical Separation Technology · Vol. 3, Issue 2, 2017 · pp. 30–35 Read article
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Nanomaterials in Modern Medicine: Synthesis,Applications, and Future Prospects
Abstract: Nanomaterials have significantly transformed the biomedical landscape, offering novelsolutions for diagnosis, treatment, and disease prevention. Their distinct physicochemicalcharacteristics such as a high surface area-to-volume ratio, tunable surface chemistry, andimproved bioavailability enable precise interactions with biological systems at the molecularlevel. This review presents a comprehensive examination of the synthesis methods andcharacterisation techniques employed to develop biomedical-grade nanomaterials, highlightingtheir structural and functional optimisation for clinical applications. Key areas of applicationdiscussed include targeted …
Published in International Journal of Nanomaterials and Nanostructures · Vol. 11, Issue 2, 2025 Read article
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Chemical Behavior and Characteristics as Related to Group V Elements in the Periodic Table and Their Electron Structures
Abstract: This research explores the interplay between electron structure and chemical behavior in Group V elements: nitrogen (N), phosphorus (P), arsenic (As), antimony (Sb), and bismuth (Bi). Nitrogen’s triple covalent bond relates to its stability and biological significance. Phosphorus’s versatile compounds benefit agriculture. Arsenic’s metalloid properties impact electronics. Antimony’s flame-retardant use highlights its versatility. Bismuth’s low toxicity and diamagnetism make it valuable in medicine and research. These elements showcase how electron …
Published in International Journal of Chemical Engineering and Processing · Vol. 10, Issue 2, 2024 · pp. 5–14 Read article
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Nanotechnology: A Technology Innovation at Nanoscale
Abstract: Nanotechnology is a field of research and technology which is mainly concerned with developing ‘things’ – mainly, devices as well as objects - at the measuring scale of atoms and molecules. The Nanotechnology is useful to broadly improve, even revolutionize, many technological as well as industrial sectors such as environmental science, medicines, homeland securities and food safety, information technology, etc. Nanotechnology plays an important in the deep study and progress …
Published in International Journal of Nanomaterials and Nanostructures · Vol. 8, Issue 1, 2022 · pp. 19–24 Read article
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Advances in Applied Chemistry: From Electrochemical Biosensors and Gas Sensing to Sustainable Remediation and Nanofluid Engineering
Abstract: Applied chemistry acts as a crucial link between fundamental molecular science and practical technological innovation. It transforms theoretical knowledge into real-world applications that address challenges in healthcare, environment, and industry. This review highlights recent advancements in electrochemical biosensors, which offer rapid and sensitive diagnostic capabilities, along with modern gas detection technologies designed for improved safety and environmental monitoring. Significant attention is given to environmental remediation, particularly the use of activated …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 1, 2026 · pp. 20–25 Read article