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10 articles for “Drug metabolism”
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A Comparative Study of Intravenous Paracetamol and Intravenous Diclofenac for Post-operative Pain Relief
Abstract: Despite advancements reducing mortality rates, adverse effects such as pain, nausea, and vomiting remain prevalent and can hinder recovery. Pain is now considered the fifth vital sign, as defined by the International Association for the Study of Pain, and inadequate pain management can result in prolonged hospital stays, increased drug use, and delayed recovery. Effective postoperative pain control is crucial in preventing respiratory complications and facilitating early discharge and return …
Published in International Journal of Analytical and Applied Chemistry · Vol. 11, Issue 1, 2025 · pp. 50–56 Read article
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Role of Human Carboxylesterase’s in Xenobiotics Metabolism
Abstract: According to one definition, xenobiotics are alien compounds that interfere with an organism's natural metabolism. Many xenobiotics can have a number of harmful effects if they don't have metabolism. There are several phase 1 metabolizing enzymes of xenobiotics which have capability to detoxify the toxic compounds. Several important metabolic detoxication enzymes are presented, including the mammalian microsomal cytochrome Carboxylesterases. Mammalian carboxyleterases are key enzymes from the serine hydrolase enzyme. Carboxylesterases …
Published in International Journal of Chemical Engineering and Processing · Vol. 11, Issue 1, 2025 · pp. 13–22 Read article
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Cryogenic Electron Microscopy Reveals Conformational Dynamics and Catalytic Mechanisms of Human Fatty Acid Synthase in De Novo Lipid Biosynthesis
Abstract: Fatty acid synthase (FASN) is a multifunctional homodimeric enzyme central to de novo fatty acid synthesis in mammals. Recent cryogenic electron microscopy (cryo-EM) studies have illuminated the structural basis of FASN catalysis, revealing multiple conformational states throughout the synthesis cycle. These findings show that the acyl carrier protein (ACP) domain dynamically shuttles substrates between spatially separated active sites, while the condensing and modifying regions remain structurally stable. In contrast to …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 2, 2026 · pp. 8–25 Read article
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A Review on the Alkaloids an Important Therapeutic Compound from Plants
Abstract: Plants have always been a basis for the traditional medicine systems and they have provided continuous remedies to the mankind for thousands of years. Therapeutic application of plants includes anti-tumor, anti-viral, anti-inflammatory, anti-malarial activities. Knowledge of the plants for the preparation of various drugs has been of great significance. Plants are considered as a rich source of wide variety of ingredients which can be used for the development of drug. …
Published in International Journal of Plant Biotechnology · Vol. 3, Issue 2, 2017 · pp. 1–9 Read article
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Useful Medicinal Operative: Innovative Formulation of Zoloft
Abstract: A highly effective antidepressant is active metabolite hydrochloride. Zoloft is one of those drugs with one or even more asymmetrical centres where the biological effects of the isomers vary significantly from one another. Depression, dependence, and other anxiety-related illnesses are all treated with sertraline hydrochloride, which selectively blocks serotonine reuptake. The preferred configurations should typically be created as early as feasible in the biosynthesis of sertraline, which has two asymmetric …
Published in International Journal of Composite Materials and Matrices · Vol. 8, Issue 1, 2022 · pp. 19–22 Read article
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Impact of Secondary Metabolism on Therapeutic Efficacy of Medicinal Plants
Abstract: Medicinal plants constitute main resource base of almost all the traditional healthcare systems. Most of the herbal drugs produced currently in majority of the developing countries lack proper quality specification and standards. Both the raw drugs and the finished herbal products manufactured contain complex mixtures of organic compounds, such as fatty acids, sterols, alkaloids, flavonoids, polyphenols, glycosides, saponins, tannins, terpenes, etc. The quality of the finished product is based on …
Published in International Journal of Plant Biotechnology · Vol. 4, Issue 2, 2018 · pp. 6–12 Read article
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Ayurveda as an alternative Medicine for SARS-CoV
Abstract: The goal of this study was to look at the clinical evidence for complementary and alternative medicine treatments for major depressive disorder. The phrase depressive disorder was combined with St John’s wort, S-adenosylmethionine (SAM-e), exercise, acupuncture, omega-3 fatty acids, and folate in a PubMed search from January 1966 to February 2010. Only relevant human trials were selected. COVID-19, the current global health emergency, is not the first-time coronaviruses have posed …
Published in International Journal of Analytical and Applied Chemistry · Vol. 7, Issue 2, 2021 · pp. 28–36 Read article
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Green synthesis of copper nanoparticles using methanol extract of Passiflora foetida and its drug delivery applications
Abstract: The present study outlines a green synthetic approach on copper nanoparticles by mixing the copper salt solution with a methanol extract of leaves of Passiflora foetida. The plant extract play as a reducing agent for copper ions in copper solution into copper nanoparticles providing a safer process. The plant extract contains numerous secondary metabolites involving in the reduction of copper ions into forming nanoparticles. The spectroscopic analysis of green synthesized …
Published in International Journal of Green Chemistry · Vol. 3, Issue 2, 2017 · pp. 31–52 Read article
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Floral System Act as a Reservoir for Nanobiotechnology (Silver Nanoparticles)
Abstract: The coming era of Nanotechnology is considered the first book on the topic of nanotechnology. It consists of processing of separation, consolidation and deformation of materials by one atom or by one molecule. There are two main approaches used in nanotechnology such as 1) “bottom-up” approach in which materials or devices are built from components and assemble themselves chemically by the principles of molecular recognition 2) “top-down” approach reflects the …
Published in International journal of Nanobiotechnology · Vol. 1, Issue 1-2, 2015 · pp. 5–7 Read article
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Possible drugs for Huntington’s disease from Capsicum annuum developed using molecular docking against Huntington protein
Abstract: Objective: To evaluate the efficacy of Capsicum annuum as a suitable plant for the treatment of Huntington’s disease using Pyrx. Huntington’s disease results in the damage of the nervous system over a period of time. For this study, we take into consideration Capsaicin, a compound obtained from the fruit of Capsicum annuum (bell pepper) responsible for giving the fruit it’s pungent odor. Studies show that Capsaicin plays a crucial role …
Published in International Journal of Animal Biotechnology and Applications · Vol. 9, Issue 2, 2023 · pp. 27–29 Read article