International Journal of Industrial Biotechnology and Biomaterials
Drug Delivery Systems
Abstract
Drug delivery is the strategy or procedure of overseeing a pharmaceutical compound to accomplish a restorative impact in human or animals. For the treatment of human illnesses, nasal and pneumonic routes of drug delivery are increasing expanding significance. These routes give promising contrasting options to parenteral drug delivery especially for peptide and protein therapeutics. For this reason, a few drug delivery frameworks have been figured and are being explored for nasal and aspiratory delivery. These incorporate liposomes, proliposomes, microspheres, gels, prodrugs, cyclodextrins, among others. Nanoparticles made out of biodegradable polymers demonstrate affirmation in satisfying the stringent prerequisites put on these delivery frameworks, for example, capacity to be moved into an airborne, security against strengths created amid aerosolization, biocompatibility, focusing of particular destinations or cell populaces in the lung, arrival of the drug in a foreordained way, and debasement inside a worthy timeframe.References (6)
- Agnihotri S.A., Mallikarjuna N.N., Aminabhavi T.M., “Recent advances on chitosan-based micro- and nanoparticles in drug delivery”, J Control Release. 2004; 100: 5–28p.
- Sood A. and Panchagnula R., “Peroral Route: An Opportunity for Protein and Peptide Drug Delivery”, Chem Rev. 2000; 101: 3275–303p.
- Niculescu-Duvaz I., Springer C.J., “Andibody-directed enzyme prodrug therapy (ADEPT): a review”, Adv Drug Deliv Rev. 1997; 26: 151–72p.
- Manabe T., Okino H., Maeyama R., Mizumoto K., Nagai E., Tanaka M., Matsuda T., “Novel strategic therapeutic approaches for prevention of local recurrence of pancreatic cancer after resection: trans-tissue, sustained local drug-delivery systems”, J Control Release. 2004; 100: 317–30p.
- Byrne M. E., Park K., Peppas N., “Molecular imprinting within hydrogels”, Adv Drug Deliv Rev. 2002; 54: 149–61p.
- Vandermeulen G. W. M., Klok H-A., “Peptide/protein hybrid material: enhanced control of structure and improved performance through conjugation of biological and synthetic polymers”, Macromol Biosci. 2003; 4: 383–98p.