In-Vitro and In-Vivo Anti-Adipogenecity Activity of Two Plants using Rat Models

Sandeep Kaur Saggi

Abstract

This study examines how extracts of plant affect the dyslipidaemic state of fatty acid induced rats. Eight days following induction for differentiation with C-DMEM and simultaneously tested with the extracts of plant (day 8), our study found significantly reduced (p < 0.05) intracellular lipid accumulations in white muscle cells in the rats. This compared positively against the smaller reduction in accumulation found in the standard drug streptozotosin (STZ). This suppressing effect was found to be dose-dependent. Additionally, cytotoxicity assay demonstrate the toxicity of different extracts in 3T3-L1 cell lines at different concentration. These results suggest that the different extracts of herbal plant has significant reduction in lipid droplet accumulations and these cell line has more than 75% cell viability. Further studies recommended exploring the potential health benefits of plants in the control of obesity and type 2 diabetes.This study examines how extracts of plant affect the dyslipidaemic state of fatty acid induced rats. Eight days following induction for differentiation with C-DMEM and simultaneously tested with the extracts of plant (day 8), our study found significantly reduced (p < 0.05) intracellular lipid accumulations in white muscle cells in the rats. This compared positively against the smaller reduction in accumulation found in the standard drug streptozotosin (STZ). This suppressing effect was found to be dose-dependent. Additionally, cytotoxicity assay demonstrate the toxicity of different extracts in 3T3-L1 cell lines at different concentration. These results suggest that the different extracts of herbal plant has significant reduction in lipid droplet accumulations and these cell line has more than 75% cell viability. Further studies recommended exploring the potential health benefits of plants in the control of obesity and type 2 diabetes.

In-Vitro and In-Vivo Anti-Adipogenecity Activity of Two Plants using Rat Models

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