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ISONIAZID STABILIZED TUNGSTEN TRICARBONYL COMPLEX: A NEW CO-RELEASING MOLECULE WITH ANTIBACTERIAL ACTIVITYBy Tenimu Adogah Abubakar, Uche B. Eke
Abstract: Transition metal carbonyl complexes substituted with biologically active ligand can act as CO-releasing molecules which have beneficial roles including antimicrobial activity. Careful choices of ancillary ligand such as isoniazid help in eliminating issues of toxicity that may arise from drug substrates. Substitution reaction of tungsten hexacarbonyl with isoniazid in the presence of trimethylamine N-oxide under nitrogen atmosphere was carried out at ambient temperature for 72 hrs. The product was characterized …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 5, Issue 1, 2019 · pp. 36–43 Read article →