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Review Paper on Mannich Bases for Heterocyclic Compound SynthesisBy S. Ravichandran, Nazmeena Kousar, R. M. Madhumitha Sri
Abstract: Mannich bases are the Lewis bases which are β-amino carbonyl compounds synthesized as the endproducts of well known condensation reaction known as Mannich reaction. These are theaminoalkylation reactions involving the formation of carbon-carbon, carbon-Nitrogen, carbonsulphurbonds. Mannich bases of 2-furylmethylketone, catechol, 4-chlorophenol, derivative ofberberine, lawsone, anisaldehyde, benzaldehyde show diversity of biological activities. Mannichreaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesisof a widespread variety …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 7, Issue 1, 2021 · pp. 39–50 Read article →