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• Published Subscription 8 Jan 2016

  Solubility Enhancement of Theophylline Drug Using Mixed Solvency Approach

  By C Jaya Kumar, M. Dharmendira Kumar

  Abstract: “Solubility enhancement” is one of the difficult tasks that have become a great challenge in formulation development of orally administered drugs having poor aqueous solubility. Poor aqueous solubility of drugs creates significant problems in producing formulations of sufficiently high bioavailability, thereby preventing the effective usage of these drugs. With the introduction of the concept of “mixed-solvency,” it is feasible to increase the solubility of poorly water-soluble drugs in aqueous solutions …

  Published in International Journal of Chemical Separation Technology · Vol. 1, Issue 2, 2015 · pp. 1–4 Read article →