2 publications

• Published Subscription 8 Mar 2025

  Nanoparticle-Based Drug Delivery System: A Review Of Recent Development And Challenges In Malaria

  By Jecinta Wanjiru Ndungu, Carolyn W. Muruthi, Jeremiah Gathirwa, Elingarami Sauli, Hulda Shaid Swai

  Abstract: Malaria remains a global health challenge despite extensive efforts in prevention and treatment. Prompt diagnosis and effective treatment are critical for eradication efforts, yet resistance to current therapeutic drugs, particularly in Plasmodium falciparum and Plasmodium vivax, poses a major obstacle. Traditional antimalarial such as quinine, chloroquine, and artemisinin-based combination therapies have been widely used, but their effectiveness is increasingly compromised by resistance and pharmacokinetic limitations. Many antimalarial drugs suffer from …

  Published in International journal of Nanobiotechnology · Vol. 11, Issue 1, 2025 Read article →

• Published Subscription 3 Oct 2024

  A Review Paper on Novel Lipid Nanoparticles for Enhanced Bioavailability of Bioactive Compounds in Breast Cancer Cell Lines

  By Jecinta Wanjiru Ndungu

  Abstract: Most bioactive compounds from natural products are heavily relied on drug development due to their biological, chemical and pharmacological properties. Some compounds exhibiting anticancer properties have also been reported. However, they present a challenge in achieving the effective absorption and delivery in the body. This is due to minimal bioavailability, fluctuation of plasma drug concentration, low tolerance, first-pass effect which leads to less desired efficacy. Therefore, this calls for an …

  Published in International Journal of Composite and Constituent Materials · Vol. 10, Issue 1, 2024 · pp. 1–9 Read article →