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Advancement of Poly-(ADP – Ribose) Polymerase (PARP) Inhibitors in Cancer Progression and TreatmentBy Neelima Chaudhary, Imteyaz Qamar
Abstract: DNA repair mechanisms are the most common and potential targets in cancer treatment. PARP enzymes play a crucial role in detection of DNA damage and its repair and also in apoptosis. Detailed knowledge of these mechanisms leads to the development of poly-(ADP-Ribose) polymerase (PARP) inhibitors as vigorous anticancer drugs with specific action. PARP inhibitors can selectivity kill tumours with deficiencies in DNA repair proteins like BRCA1/2, exploiting synthetic lethality concept. …
Published in International Journal of Animal Biotechnology and Applications · Vol. 1, Issue 1, 2015 Read article →