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• Published Subscription 28 May 2020

  Thiamine Hydrochloride (VB1) in Water: A Privileged Synthetic Route to Benzimidazole Derivatives

  By Suchita S. Gadekar, Suryakant B. Sapkal, Balaji R. Madje

  Abstract: Thiamine hydrochloride (VB1) is found to be an inexpensive, efficient, non-toxic and mild catalyst for the cyclocondensation of o-phenylinediamine and aromatic/heteroaromatic/aliphatic aldehydes in water at moderate temperature. The present work contributes a greener approach for the synthesis of benzimidazole derivatives under gracious (water) reaction medium which resulted into facile, sustainable and high yielding methodology. Keywords: benzimidazoles, sustainable chemistry, thiamine hydrochloride (VB1), water

  Published in International Journal of Green Chemistry · Vol. 2, Issue 1, 2016 · pp. 1–8 Read article →